1,3-Benzodioxole, 5-[3-(2-azidoethyl)-1-cyclohexen-1-yl]-

Base Information

Chemical Name:1,3-Benzodioxole, 5-[3-(2-azidoethyl)-1-cyclohexen-1-yl]-
CAS No.:144344-97-8
Molecular Formula:C15H17N3O2
Molecular Weight:271.319
Hs Code.:
DSSTox Substance ID:DTXSID70455528

Synonyms:144344-97-8;1,3-Benzodioxole, 5-[3-(2-azidoethyl)-1-cyclohexen-1-yl]-;DTXSID70455528

Suppliers and Price of 1,3-Benzodioxole, 5-[3-(2-azidoethyl)-1-cyclohexen-1-yl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,3-Benzodioxole, 5-[3-(2-azidoethyl)-1-cyclohexen-1-yl]-

Chemical Property:

XLogP3:4.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:271.132076794
Heavy Atom Count:20
Complexity:417

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC(C=C(C1)C2=CC3=C(C=C2)OCO3)CCN=[N+]=[N-]

Technology Process of 1,3-Benzodioxole, 5-[3-(2-azidoethyl)-1-cyclohexen-1-yl]-

There total 14 articles about 1,3-Benzodioxole, 5-[3-(2-azidoethyl)-1-cyclohexen-1-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 141090-97-3
1-<3,4-(Methylenedioxy)phenyl>-3-<(ethoxycarbonyl)methyl>cyclohex-1-ene

: 144344-97-8
1-<3,4-(Methylenedioxy)phenyl>-3-(2-azidoethyl)cyclohex-1-ene

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

2: 1.) CH₃SO₂Cl, Et₃N, 2.) Bu₄NN₃ / 1.) CH₂Cl₂, -50 deg C, 1 h, 2.) THF, 9 h

With lithium aluminium tetrahydride; tetrabutylammoniun azide; methanesulfonyl chloride; triethylamine; In tetrahydrofuran;
DOI:10.1021/ja00075a038

Reference yield:

: 144412-93-1
1-<3,4-(Methylenedioxy)phenyl>-3-(2-hydroxyethyl)cyclohex-1-ene

: 144344-97-8
1-<3,4-(Methylenedioxy)phenyl>-3-(2-azidoethyl)cyclohex-1-ene

Guidance literature:: With tetrabutylammoniun azide; methanesulfonyl chloride; triethylamine; Yield given. Multistep reaction; 1.) CH₂Cl₂, -50 deg C, 1 h, 2.) THF, 9 h;
DOI:10.1021/ja00075a038

Reference yield:

: 6642-34-8
6-bromopiperonyl alcohol

: 144344-97-8
1-<3,4-(Methylenedioxy)phenyl>-3-(2-azidoethyl)cyclohex-1-ene

Guidance literature:: Multi-step reaction with 7 steps

1: 1) n-BuLi / 1) ether, hexane, -78 deg C, 5 min, 2) a) to 23 deg C, 2 h, b) 23 deg C, 8 h

2: 89 percent / imidazole / tetrahydrofuran / 8 h / 23 °C

3: 74 percent / LiClO₄ / diethyl ether / 24 h / 23 °C

4: 97 percent / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

5: Et₃N / CH₂Cl₂ / 1 h / -50 °C

6: Bu₄NN₃ / tetrahydrofuran / 2 h

7: Bu₄NN₃ / tetrahydrofuran / 9 h

With 1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; lithium perchlorate; tetrabutylammoniun azide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo00051a021