α-[4-(3,4-Dihydroxyphenyl)-3-hydroxy-5-oxofuran-2(5H)-ylidene]-4-hydroxybenzeneacetic acid

Base Information

Chemical Name:α-[4-(3,4-Dihydroxyphenyl)-3-hydroxy-5-oxofuran-2(5H)-ylidene]-4-hydroxybenzeneacetic acid
CAS No.:25287-88-1
Molecular Formula:C18H12 O8
Molecular Weight:356.288
Hs Code.:
Mol file:25287-88-1.mol

Synonyms:D2(5H),a-Furanacetic acid, 4-(3,4-dihydroxyphenyl)-3-hydroxy-a-(p-hydroxyphenyl)-5-oxo- (8CI);Xerocomic acid

Suppliers and Price of α-[4-(3,4-Dihydroxyphenyl)-3-hydroxy-5-oxofuran-2(5H)-ylidene]-4-hydroxybenzeneacetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of α-[4-(3,4-Dihydroxyphenyl)-3-hydroxy-5-oxofuran-2(5H)-ylidene]-4-hydroxybenzeneacetic acid

Chemical Property:

PSA：144.52000
LogP:2.12520

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of α-[4-(3,4-Dihydroxyphenyl)-3-hydroxy-5-oxofuran-2(5H)-ylidene]-4-hydroxybenzeneacetic acid

There total 10 articles about α-[4-(3,4-Dihydroxyphenyl)-3-hydroxy-5-oxofuran-2(5H)-ylidene]-4-hydroxybenzeneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: benzyl [3-benzyloxy-4-(3,4-bis(benzyloxy)phenyl)-5-oxo-5H-furan-2-ylidene](4-benzyloxyphenyl)acetate

: 25287-88-1
[4-(3,4-dihydrophenyl)-3-hydroxy-5-oxo-5H-furan-2-ylidene](4-hydroxyphenyl)acetic acid

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In N,N-dimethyl-formamide; for 2.5h; under 760.051 Torr;
DOI:10.1016/j.tet.2008.06.058

Reference yield:

: 5447-02-9
3,4-dibenzyloxybenzaldehyde

: 25287-88-1
[4-(3,4-dihydrophenyl)-3-hydroxy-5-oxo-5H-furan-2-ylidene](4-hydroxyphenyl)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 86 percent / HCl (gas) / CHCl₃ / 1.) 1 h, 2.) -20 deg C, 10 min, 3.) room temperature, 1 h

2: 1.) n-butyllithium / 1.) THF, -78 deg C, hexane, 1 h, 2.) overnight, room temperature, 3.) ether

3: 58 percent / CuO, CuCl₂ / acetone; H₂O / 3.5 h / Heating

4: toluene / 18 h / 80 °C

5: 1.) lithium di-isopropylamide / 1.) -78 deg C, 25 min, THF, 2.) overnight, room temperature

6: hydrogen, aq. HCl / Pd-C / dimethylformamide / 3.5 h / Ambient temperature

7: TFA, anisole / 16 h / Ambient temperature

With hydrogenchloride; n-butyllithium; hydrogen; methoxybenzene; trifluoroacetic acid; copper(II) oxide; copper dichloride; lithium diisopropyl amide; palladium on activated charcoal; In chloroform; water; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 58594-01-7
2-(3,4-bis(benzyloxy)phenyl)-1,3-dithiane

: 25287-88-1
[4-(3,4-dihydrophenyl)-3-hydroxy-5-oxo-5H-furan-2-ylidene](4-hydroxyphenyl)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-butyllithium / 1.) THF, -78 deg C, hexane, 1 h, 2.) overnight, room temperature, 3.) ether

2: 58 percent / CuO, CuCl₂ / acetone; H₂O / 3.5 h / Heating

3: toluene / 18 h / 80 °C

4: 1.) lithium di-isopropylamide / 1.) -78 deg C, 25 min, THF, 2.) overnight, room temperature

5: hydrogen, aq. HCl / Pd-C / dimethylformamide / 3.5 h / Ambient temperature

6: TFA, anisole / 16 h / Ambient temperature

With hydrogenchloride; n-butyllithium; hydrogen; methoxybenzene; trifluoroacetic acid; copper(II) oxide; copper dichloride; lithium diisopropyl amide; palladium on activated charcoal; In water; N,N-dimethyl-formamide; acetone; toluene;