58594-01-7

Upstream product

• 109-80-8 1.3-propanedithiol 
• 5447-02-9 3,4-dibenzyloxybenzaldehyde 

Downstream Products

• 93796-44-2 2-(3,4-dibenzyloxyphenyl)-2-methoxycarbonyl-1,3-dithiane 
• 93796-46-4 (Z)-5'-<α-methoxycarbonyl-(3,4-dibenzyloxybenzylidene)>cyclohexanespiro-2'-(1',3'-dioxolan)-4'-one 
• 93796-46-4 (E)-5'-<α-methoxycarbonyl-(3,4-dibenzyloxybenzylidene)>cyclohexanespiro-2'-(1',3'-dioxolan)-4'-one 
• 93796-47-5 (E)-2-(3,4-dibenzyloxyphenyl)-4-(α-t-butoxycarbonyl-4-benzyloxybenzylidene)tetronic acid 
• 93796-45-3 methyl 3,4-dibenzyloxyphenylglyoxylate 
• 19712-89-1 tert-butyl 2-(4-benzyloxyphenyl)acetate 
• 25287-88-1 [4-(3,4-dihydrophenyl)-3-hydroxy-5-oxo-5H-furan-2-ylidene](4-hydroxyphenyl)acetic acid 

Relevant academic research and scientific papers

Design, synthesis, and evaluation of DNA topoisomerase II-targeted nucleosides

We developed novel nucleoside-based topoisomerase II selective inhibitors and showed that small structural units, such as catechols, are essential for DNA topoisomerase II inhibitory activity. Moreover, nucleoside analogues containing TBS and 1,3-dithian

Dioxolanones as Synthetic Intermediates. Part 3. Biomimetic Synthesis of Pulvinic Acids

The reaction of the phosphorane (16) with methyl arylglyoxylates gives 5-(α-methoxycarbonylarylidene)-2,2-pentamethylene-1,3-dioxolan-4-ones which have been treated with the lithium enolates of t-butyl phenylacetic esters to provide a biomimetic synthesis of pulvinic acids.By this method pulvinic acid (2), vulpinic acid (1), and the unsymmetrically substituted compounds, leprapinic acid (3), and xerocomic acid (4) have been prepared; the last named was obtained via an intermediate (28) in which the phenolic groups were protected as benzyl ethers.