1H-Indole-2-carboxamide, N-(2-(7-methoxy-1-naphthalenyl)ethyl)-

Base Information

• Chemical Name: 1H-Indole-2-carboxamide, N-(2-(7-methoxy-1-naphthalenyl)ethyl)-
• CAS No.: 138112-95-5
• Molecular Formula: C22H20N2O2
• Molecular Weight: 344.4064
• DSSTox Substance ID: DTXSID30160484
• Nikkaji Number: J481.060K
• Wikidata: Q83028849
• ChEMBL ID: CHEMBL37341
• Mol file: 138112-95-5.mol

Synonyms:N-(2-(7-Methoxynaphth-1-yl)ethyl)indolecarboxamide;1H-Indole-2-carboxamide, N-(2-(7-methoxy-1-naphthalenyl)ethyl)-;CHEMBL37341;N-(2-(7-Methoxy-1-naphthalenyl)ethyl)-1H-indole-2-carboxamide;138112-95-5;N-[2-(7-Methoxy-1-naphthalenyl)ethyl]-1H-indole-2-carboxamide;SCHEMBL9491485;DTXSID30160484;BDBM50037234;LS-82511;1H-Indole-2-carboxylic acid [2-(7-methoxy-naphthalen-1-yl)-ethyl]-amide

Chemical Property of 1H-Indole-2-carboxamide, N-(2-(7-methoxy-1-naphthalenyl)ethyl)-

Chemical Property:

• Vapor Pressure: 2.75E-17mmHg at 25°C
• Refractive Index: 1.687
• Boiling Point: 659.9°Cat760mmHg
• Flash Point: 352.9°C
• Density: 1.24g/cm³
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 344.152477885
• Heavy Atom Count: 26
• Complexity: 483

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=CC=C2CCNC(=O)C3=CC4=CC=CC=C4N3)C=C1

Technology Process of 1H-Indole-2-carboxamide, N-(2-(7-methoxy-1-naphthalenyl)ethyl)-

There total 6 articles about 1H-Indole-2-carboxamide, N-(2-(7-methoxy-1-naphthalenyl)ethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

Indole-2-carbonyl chloride (58881-45-1) + 2-(7-methoxynaphthalen-1-yl)ethanamine hydrochloride (139525-77-2) → S 20255 (138112-95-5)

Guidance literature:

With potassium carbonate; In chloroform; water; for 0.5h; Ambient temperature;

DOI:10.1021/jm00046a006

Reference yield:

2-(7-methoxynaphthalen-1-yl)acetic acid (6836-22-2) → S 20255 (138112-95-5)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride / CHCl₃

2: aq. NH₄OH / diethyl ether / 0 °C

3: AlH₄ / diethyl ether

4: K₂CO₃ / H₂O; CHCl₃ / 0 °C

With ammonium hydroxide; thionyl chloride; potassium carbonate; tetrahydridoaluminate; In diethyl ether; chloroform; water;

DOI:10.1021/jm00086a018

Reference yield:

2-(2-methoxynaphthalen-8-yl)acetamide (138113-07-2) → S 20255 (138112-95-5)

Guidance literature:

Multi-step reaction with 2 steps

1: AlH₄ / diethyl ether

2: K₂CO₃ / H₂O; CHCl₃ / 0 °C

With potassium carbonate; tetrahydridoaluminate; In diethyl ether; chloroform; water;

DOI:10.1021/jm00086a018

upstream raw materials:

Indole-2-carbonyl chloride

2-(7-methoxynaphthalen-1-yl)ethanamine hydrochloride

2-(7-methoxynaphthalen-1-yl)acetic acid

2-(2-methoxynaphthalen-8-yl)acetamide