139525-77-2 Usage
Description
2-(7-Methoxy-1-naphthyl)ethylamine hydrochloride is an organic compound with the molecular formula C18H20ClNO and is characterized by its amine functional group and a naphthalene ring with a methoxy substituent. It is a white crystalline solid and is used as a reagent in the pharmaceutical industry for the synthesis of various compounds.
Uses
Used in Pharmaceutical Industry:
2-(7-Methoxy-1-naphthyl)ethylamine hydrochloride is used as a reagent for the synthesis of antidepressant agomelatine through a tandem allylic chlorination-isomerization process. 2-(7-Methoxy-1-naphthyl)ethylamine hydrochloride plays a crucial role in the development of novel antidepressant medications, which can help alleviate symptoms of depression and improve the quality of life for patients.
Additionally, 2-(7-Methoxy-1-naphthyl)ethylamine hydrochloride is used as a reagent in the design, preparation, and in vitro evaluation of melatonin derivatives as serotonin N-acetyltransferase inhibitors. These derivatives have the potential to regulate the sleep-wake cycle and improve sleep quality, making them valuable in the treatment of sleep disorders and circadian rhythm disturbances.
Furthermore, this compound is also known as Agomelatine Impurity 5, which is an impurity found in the synthesis process of agomelatine. The identification and control of such impurities are essential for ensuring the safety, efficacy, and quality of the final pharmaceutical product.
Check Digit Verification of cas no
The CAS Registry Mumber 139525-77-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,5,2 and 5 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 139525-77:
(8*1)+(7*3)+(6*9)+(5*5)+(4*2)+(3*5)+(2*7)+(1*7)=152
152 % 10 = 2
So 139525-77-2 is a valid CAS Registry Number.
InChI:InChI=1/C13H15NO.ClH/c1-15-12-6-5-10-3-2-4-11(7-8-14)13(10)9-12;/h2-6,9H,7-8,14H2,1H3;1H
139525-77-2Relevant articles and documents
PROCESS FOR THE PREPARATION OF AGOMELATINE IN CRYSTALLINE FORM
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Page/Page column 41, (2019/05/02)
The present invention pertains to a process for the preparation of polymorph form X of agomelatine, which comprises providing agomelatine, and crystallizing agomelatine in the presence of at least one of an acid and a salt thereof, and to a polymorph form of agomelatine.
Preparation method of Agomelatine
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Paragraph 0022-0033, (2017/08/30)
The invention relates to a preparation method of Agomelatine. The preparation method comprises the steps of directly reducing a raw material 4-methylbenzenesulfonic acid 1-(cyano methyl)-7-methoxynaphthalene-2-estoral into 2-(7-methoxyl-1-naphthyl) ethylamine, and then further transforming into the Agomelatine. The preparation method of the Agomelatine provided by the invention is less in reaction step, high in yield/purity, and simple in aftertreatment.
A NOVEL PROCESS FOR THE PREPARATION OF TETRALIN AND NAPHTHALENE DERIVATIVES
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, (2015/01/16)
The present invention relates to a novel process for the preparation or tetralin and naphthalene derivatives, including Agomelatine and pharmaceutical acceptable salts thereof. Such compounds are considered to be interesting either as useful building blocks or due to their biological activity.
