4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid

Base Information

• Chemical Name: 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid
• CAS No.: 144690-04-0
• Molecular Formula: C10H16N2O3
• Molecular Weight: 212.249
• Mol file: 144690-04-0.mol

Synonyms:4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate;

Chemical Property of 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid

Chemical Property:

• Boiling Point: 489.8±35.0 °C(Predicted)
• PKA: 2.52±0.36(Predicted)
• PSA: 86.21000
• Density: 1.244±0.06 g/cm3(Predicted)
• LogP: 1.28780

Purity/Quality:

NLT 98% ^*data from raw suppliers

4-(2-Hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

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Technology Process of 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid

There total 2 articles about 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

C10H14N2O2 (849206-42-4) → 4-(1-hydroxy-1-methylethyl)-2-propyl imidazole-5-carboxylic acid (144690-04-0)

Guidance literature:

C₁₀H₁₄N₂O₂; With water; sodium hydroxide; In acetone; Reflux;

With hydrogenchloride; In water;

Reference yield: 95.0%

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate (144689-93-0) → 4-(1-hydroxy-1-methylethyl)-2-propyl imidazole-5-carboxylic acid (144690-04-0)

Guidance literature:

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate; With water; sodium hydroxide; In acetone; for 3h; Reflux;

With hydrogenchloride; In water; at 10 ℃; pH=6.5;

Reference yield: 85.0%

4-(1-hydroxy-1-methylethyl)-2-propyl imidazole-5-carboxylic acid (144690-04-0) + ethanol (64-17-5) → ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate (144689-93-0)

Guidance literature:

4-(1-hydroxy-1-methylethyl)-2-propyl imidazole-5-carboxylic acid; ethanol; With thionyl chloride; Reflux;

With sodium hydrogencarbonate; In water; ethyl acetate; Product distribution / selectivity;

upstream raw materials:

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

C₁₀H₁₄N₂O₂

Downstream raw materials:

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({2'-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1'-biphenyl]-4-yl}methyl)-1H-imidazole-5-carboxylate

1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-{[2'-(1H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1H-imidazole-5-carboxylate

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