4-Pentenoic acid, 3-ethyl-5-(4-morpholinyl)-5-phenyl-, 1,1-dimethylethyl ester, (E)-

Base Information

Chemical Name:4-Pentenoic acid, 3-ethyl-5-(4-morpholinyl)-5-phenyl-, 1,1-dimethylethyl ester, (E)-
CAS No.:144723-59-1
Molecular Formula:C₂₁H₃₁NO₃
Molecular Weight:345.482
Hs Code.:
Mol file:144723-59-1.mol

Synonyms:

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Chemical Property of 4-Pentenoic acid, 3-ethyl-5-(4-morpholinyl)-5-phenyl-, 1,1-dimethylethyl ester, (E)-

Chemical Property:

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Technology Process of 4-Pentenoic acid, 3-ethyl-5-(4-morpholinyl)-5-phenyl-, 1,1-dimethylethyl ester, (E)-

There total 3 articles about 4-Pentenoic acid, 3-ethyl-5-(4-morpholinyl)-5-phenyl-, 1,1-dimethylethyl ester, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(2-Bromo-1-phenyl-ethylidene)-morpholin-4-ium

: 144723-59-1
(E)-3-Ethyl-5-morpholin-4-yl-5-phenyl-pent-4-enoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / diethyl ether / -20 deg C to room temp.

2: 1.) tert-butyllithium / 1.) pentane/THF, -78 deg C, 40 min 2.) THF, -78 deg C, 2 h; -78 to 0 deg C, 4 h; quenching with buffer pH 7

With tert.-butyl lithium; triethylamine; In diethyl ether;
DOI:10.1055/s-1991-26536

Reference yield:

: 7196-01-2
4-(1-phenylvinyl)morpholine

: 144723-59-1
(E)-3-Ethyl-5-morpholin-4-yl-5-phenyl-pent-4-enoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Br₂ / diethyl ether / -60 deg C, 30 min; then 0 deg C

2: Et₃N / diethyl ether / -20 deg C to room temp.

3: 1.) tert-butyllithium / 1.) pentane/THF, -78 deg C, 40 min 2.) THF, -78 deg C, 2 h; -78 to 0 deg C, 4 h; quenching with buffer pH 7

With bromine; tert.-butyl lithium; triethylamine; In diethyl ether;
DOI:10.1055/s-1991-26536

Reference yield:

: 81643-03-0
(2E)-2-pentenoic acid tert-butyl ester

: 136843-98-6
4-((E)-2-Bromo-1-phenyl-vinyl)-morpholine

: 144723-59-1
(E)-3-Ethyl-5-morpholin-4-yl-5-phenyl-pent-4-enoic acid tert-butyl ester

: 3-Ethyl-2-((E)-1-ethyl-3-morpholin-4-yl-3-phenyl-allyl)-pentanedioic acid di-tert-butyl ester

Guidance literature:: With tert.-butyl lithium; Yield given. Multistep reaction; 1.) pentane/THF, -78 deg C, 40 min 2.) THF, -78 deg C, 2 h; -78 to 0 deg C, 4 h; quenching with buffer pH 7;
DOI:10.1055/s-1991-26536