Benzamide, 3-chloro-5-ethyl-6-hydroxy-2-methoxy-N-[[1-[2-[(methylsulfonyl)oxy]ethyl]- 2-pyrrolidinyl]methyl]-, (S)-

Base Information

Chemical Name:Benzamide, 3-chloro-5-ethyl-6-hydroxy-2-methoxy-N-[[1-[2-[(methylsulfonyl)oxy]ethyl]- 2-pyrrolidinyl]methyl]-, (S)-
CAS No.:144765-78-6
Molecular Formula:C18H27ClN2O6S
Molecular Weight:434.941
Hs Code.:
Mol file:144765-78-6.mol

Synonyms:

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Chemical Property of Benzamide, 3-chloro-5-ethyl-6-hydroxy-2-methoxy-N-[[1-[2-[(methylsulfonyl)oxy]ethyl]- 2-pyrrolidinyl]methyl]-, (S)-

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Technology Process of Benzamide, 3-chloro-5-ethyl-6-hydroxy-2-methoxy-N-[[1-[2-[(methylsulfonyl)oxy]ethyl]- 2-pyrrolidinyl]methyl]-, (S)-

There total 6 articles about Benzamide, 3-chloro-5-ethyl-6-hydroxy-2-methoxy-N-[[1-[2-[(methylsulfonyl)oxy]ethyl]- 2-pyrrolidinyl]methyl]-, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 124-63-0
methanesulfonyl chloride

: 144765-76-4
(S)-(-)-5-chloro-3-ethyl-N-<<1-(2'-hydroxyethyl)-2-pyrrolidinyl>methyl>-6-methoxysalicylamide

: 144765-78-6
(S)-(-)-5-chloro-3-ethyl-N-<<1-(2'-methanesulfonyloxyethyl)-2-pyrrolidinyl>methyl>-6-methoxysalicylamide

Guidance literature:: With triethylamine; In diethyl ether; at 0 ℃; for 0.25h;
DOI:10.1248/cpb.40.1793

Reference yield:

: 101536-78-1
3-chloro-5-ethyl-6-hydroxy-2-methoxybenzoic acid

: 144765-78-6
(S)-(-)-5-chloro-3-ethyl-N-<<1-(2'-methanesulfonyloxyethyl)-2-pyrrolidinyl>methyl>-6-methoxysalicylamide

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂ / 0.25 h / 0 °C

2: CH₂Cl₂ / 0.33 h / Ambient temperature

3: 94 percent / 1 N HCl / 1 h / Ambient temperature

4: 63 percent / Et₃N / diethyl ether / 0.25 h / 0 °C

With hydrogenchloride; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1248/cpb.40.1793

Reference yield:

: 1027381-87-8
(S)-2-aminomethyl-1-(2'-tetrahydropyranyloxyethyl)pyrrolidine

: 144765-78-6
(S)-(-)-5-chloro-3-ethyl-N-<<1-(2'-methanesulfonyloxyethyl)-2-pyrrolidinyl>methyl>-6-methoxysalicylamide

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂ / 0.33 h / Ambient temperature

2: 94 percent / 1 N HCl / 1 h / Ambient temperature

3: 63 percent / Et₃N / diethyl ether / 0.25 h / 0 °C

With hydrogenchloride; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1248/cpb.40.1793