Benzo[b]thiophene-3-carboxylic acid, 2-[[[(4-bromophenyl)amino]thioxomethyl]amino]-4,5,6,7-tetrahydro-, ethyl ester

Base Information

• Chemical Name: Benzo[b]thiophene-3-carboxylic acid, 2-[[[(4-bromophenyl)amino]thioxomethyl]amino]-4,5,6,7-tetrahydro-, ethyl ester
• CAS No.: 144846-20-8
• Molecular Formula: C18H19BrN2O2S2
• Molecular Weight: 439.397
• Mol file: 144846-20-8.mol

Synonyms:

Chemical Property of Benzo[b]thiophene-3-carboxylic acid, 2-[[[(4-bromophenyl)amino]thioxomethyl]amino]-4,5,6,7-tetrahydro-, ethyl ester

Chemical Property:

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Technology Process of Benzo[b]thiophene-3-carboxylic acid, 2-[[[(4-bromophenyl)amino]thioxomethyl]amino]-4,5,6,7-tetrahydro-, ethyl ester

There total 2 articles about Benzo[b]thiophene-3-carboxylic acid, 2-[[[(4-bromophenyl)amino]thioxomethyl]amino]-4,5,6,7-tetrahydro-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

ethyl 2-isothiocyanato-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (85716-87-6) + 4-bromo-aniline (106-40-1) → N1-(3-carbethoxy-4,5,6,7-tetrahydrobenzothien-2-yl)-N2-p-bromophenylthiourea (144846-20-8)

Guidance literature:

In ethanol; Heating;

DOI:10.1023/B:COHC.0000003515.53486.4d

Reference yield:

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (4506-71-2) + 4-Bromophenyl isothiocyanate (1985-12-2) → N1-(3-carbethoxy-4,5,6,7-tetrahydrobenzothien-2-yl)-N2-p-bromophenylthiourea (144846-20-8)

Guidance literature:

In ethanol; for 6h; Heating;

Reference yield: 87.0%

N1-(3-carbethoxy-4,5,6,7-tetrahydrobenzothien-2-yl)-N2-p-bromophenylthiourea (144846-20-8) → potassium; 3-(4-bromo-phenyl)-4-oxo-3,4,5,6,7,8-hexahydro-benzo[4,5]thieno[2,3-d]pyrimidine-2-thiolate

Guidance literature:

With potassium hydroxide; In ethanol; Heating;

DOI:10.1023/B:COHC.0000003515.53486.4d

upstream raw materials:

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

4-Bromophenyl isothiocyanate

ethyl 2-isothiocyanato-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

4-bromo-aniline

Downstream raw materials:

3-(4-bromo-phenyl)-2-mercapto-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one

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