Glycine, N-(N-L-methionyl-L-leucyl)-

Base Information

• Chemical Name: Glycine, N-(N-L-methionyl-L-leucyl)-
• CAS No.: 14486-11-4
• Molecular Formula: C13H25N3O4S
• Molecular Weight: 319.42000
• Hs Code.: 2930909090
• DSSTox Substance ID: DTXSID00427218
• Nikkaji Number: J307.655E
• Metabolomics Workbench ID: 84063
• Mol file: 14486-11-4.mol

Synonyms:H-Met-Leu-Gly-OH;14486-11-4;Glycine, N-(N-L-methionyl-L-leucyl)-;Met-Leu-Gly;2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-4-methylpentanoyl]amino]acetic acid;H-Met-Leu-Gly;Methionyl-leucyl-glycine;L-Methionyl-L-leucyl-glycine;DTXSID00427218;CHEBI:160859;HZVXPUHLTZRQEL-UWVGGRQHSA-N;N-(N-L-Methionyl-L-leucyl)glycine;MFCD00238086;2-[[(2S)-2-[[(2S)-2-amino-4-methylsulanylbutanoyl]amino]-4-methylpentanoyl]amino]acetic acid;2-[[(2S)-2-[[(2S)-2-azaniumyl-4-methylsulfanylbutanoyl]amino]-4-methylpentanoyl]amino]acetate

Chemical Property of Glycine, N-(N-L-methionyl-L-leucyl)-

Chemical Property:

• PSA: 153.80000
• LogP: 2.17940
• XLogP3: -2.5
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 10
• Exact Mass: 319.15657746
• Heavy Atom Count: 21
• Complexity: 363

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)NCC(=O)O)NC(=O)C(CCSC)N
• Isomeric SMILES: CC(C)C[C@@H](C(=O)NCC(=O)O)NC(=O)[C@H](CCSC)N

Technology Process of Glycine, N-(N-L-methionyl-L-leucyl)-

There total 3 articles about Glycine, N-(N-L-methionyl-L-leucyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

Tert-butyloxycarbonylmethionyl-leucyl-glycine ethyl ester (29389-58-0) → methionyl-leucyl-glycine (14486-11-4)

Guidance literature:

With trifluoroacetic acid; for 1h; Ambient temperature;

DOI:10.1135/cccc19801305

Reference yield:

Benzyloxycarbonylleucyl-glycine ethyl ester (2867-06-3) → methionyl-leucyl-glycine (14486-11-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) HBr, 2.) N-ethylpiperidine, 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / 1.) acetic acid, R_.T_., 20 min, 2.) dimethylformamide, -20 deg C, pH 7.5 to 8.0, 1 h at -10 deg C, 12 h at 0 deg C_.

2: 53 percent / trifluoroacetic acid / 1 h / Ambient temperature

With 1-ethyl-piperidine; hydrogen bromide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid;

DOI:10.1135/cccc19801305

Reference yield:

→ methionyl-leucyl-glycine (14486-11-4)

Guidance literature:

upstream raw materials:

Tert-butyloxycarbonylmethionyl-leucyl-glycine ethyl ester

Benzyloxycarbonylleucyl-glycine ethyl ester