2867-06-3

Basic information

• Product Name: ethyl N-[(benzyloxy)carbonyl]leucylglycinate
• CAS NO: 2867-06-3
• Molecular Formula: C₁₈H₂₆N₂O₅
• Molecular Weight: 350.4094
• Mol File: 2867-06-3.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 526.2°C at 760 mmHg
• Flash Point: 272°C
• Density: 1.131g/cm³
• Vapor Pressure: 3.67E-11mmHg at 25°C
• Refractive Index: 1.511
• CAS DataBase Reference: ethyl N-[(benzyloxy)carbonyl]leucylglycinate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl N-[(benzyloxy)carbonyl]leucylglycinate(2867-06-3)
• EPA Substance Registry System: ethyl N-[(benzyloxy)carbonyl]leucylglycinate(2867-06-3)

Safety Data

• Hazardous Substances Data: 2867-06-3(Hazardous Substances Data)

Upstream product

• 623-33-6 glycine ethyl ester hydrochloride 
• 19648-62-5 [4-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyloxy)-phenyl]-trimethyl-ammonium; iodide 
• 2018-66-8 Z-Leu-OH 
• 814-49-3 diethyl chlorophosphate 
• 459-73-4 GlyOEt*HCl 
• 501-53-1 benzyl chloroformate 
• 61-90-5 L-leucine 
• 4703-53-1 N-benzyloxycarbonyl-L-leucine hydrazide 
• 58889-73-9 (S)-N-benzyloxycarbonyl-leucine ethyl ester 
• 61487-89-6 C₂₃H₂₆N₂O₅ 
• 87024-12-2 (S)-1-(2'-benzyloxycarbonylamino-4'-methylpentanoyl)-3,5-dimethylpyrazole 
• 53363-87-4 N-(benzyloxycarbonyl)leucine dicyclohexylamine salt 
• 4091-51-4 N-Benzyloxycarbonyl-L-leucin- 
• 76863-45-1 (S)-benzyl (1-azido-4-methyl-1-oxopentan-2-yl)carbamate 

Downstream Products

• 53375-57-8 H-Leu-Gly-OEt 
• 2706-38-9 N-(N-benzyloxycarbonyl-L-leucyl)-glycine 
• 2766-19-0 Z-Gly-Leu-Gly-OEt 
• 7784-82-9 N-[N-(N-benzyloxycarbonyl-L-prolyl)-L-leucyl]glycine ethyl ester 
• 27461-77-4 N-benzyloxycarbonyl-L-leucylaminoethanol 
• 19739-60-7 Cbz-leucylglycyl hydrazide 
• 88463-37-0 Benzyloxycarbonyl-S-benzylcysteinyl-tyrosyl-isoleucyl-glutaminyl-aparaginyl-S-benzylcystein-1-aminocyclopropane-1-carboxy-leucyl-glycine Amide 
• 14486-11-4 methionyl-leucyl-glycine 
• 88463-33-6 Benzyloxycarbonyl-1-aminocyclopropane-1-carboxy-leucyl-glycine Amide 
• 91682-45-0 Benzyloxycarbonyl-1-aminocyclopropane-1-carboxy-leucyl-glycine Ethyl Ester 
• 88463-32-5 <7-(1-Aminocyclopropanecarboxylic acid)>oxytocin 
• 14485-80-4 benzoyloxycarbonylprolyl-leucyl-glycine amide 
• 686-50-0 L-leucyl-glycine 
• 14297-22-4 N-[N-(N-benzyloxycarbonyl-L-leucyl)-glycyl]-glycine 

Relevant articles and documents

Facile and purification free synthesis of peptides utilizing ROMPgel- and ROMPsphere-supported coupling reagents

5-Norbornene-2-carboxaldehyde and norbornadiene were respectively converted into norbornene derivatives functionalized with fluoroformamidinium hexafluorophosphate and 2-bromo-N-methylpyridinium tetrafluoroborate residues. Both these norbornene monomers were ring opening metathesis polymerized or graft copolymerized onto polystyrene cores to produce ROMPgel and ROMPsphere peptide-coupling reagents. These were used to prepare hindered amides, dipeptides and tripeptides with minimal purification in parallel arrays.

Asymmetric alcoholysis of 2-phenyl-5(4H)-oxazolones by the catalytic mixture of cyclo[(S)-His-(S)-Phe] with chiral auxiliaries

Some derivatives of dipeptides containing a His residue catalyzed the ring opening of 2-phenyl-4-benzyl-5(4H)-oxazolone by methanol. The mixture of cyclo[(S)-His-(S)-Phe] (CHP) with chiral auxiliaries which possess both a hydrogen-bond donor and a hydroge

Organophosphorus esters of 1-hydroxy-2-phenylbenzimidazole: Synthesis and utilization as novel peptide coupling reagents

Highly efficient coupling reagents - phosphoric acid diethyl ester 2-phenylbenzimidazol-1-yl ester, diphenylphosphinic acid 2-phenylbenzimidazol-1- yl ester and phosphoric acid diphenyl ester 2-phenylbenzimidazol-1-yl ester - were designed, synthesized and successfully applied in peptide coupling reactions. Their efficiency was evaluated through the synthesis of a range of amides and peptides, and the extent of racemization was studied by HPLC and found to be negligible. The mechanism of action is probably similar to those found for organophoshorus esters of hydroxybenzotriazole: a presumption supported by the isolation and characterization by mass spectrometry and 1H NMR of some of the proposed intermediates. Georg Thieme Verlag Stuttgart.

A new method for the synthesis of carboxamides and peptides using 1,1′-carbonyldioxydi[2(1H)-pyridone] (CDOP) in the absence of basic promoters

Various carboxamides or peptides are synthesized from the corresponding carboxylic acids and amines or α-amino acids using 1,1′-carbonyldioxydi[2(1H)-pyridone]. The reaction proceeds in the absence of basic promoters such as triethylamine or 4-(dimethylamino)pyridine, therefore, the undesired racemization does not occur at all in the segment coupling producing Z-Gly-Phe-Val-OMe and Z-Phe-Val-Ala-OMe.