3-(2-Aminoethoxy)propanoic acid

Base Information

• Chemical Name: 3-(2-Aminoethoxy)propanoic acid
• CAS No.: 144942-89-2
• Molecular Formula: C5H11NO3
• Molecular Weight: 0.00000
• Hs Code.: 2942000090
• European Community (EC) Number: 893-139-9
• Mol file: 144942-89-2.mol

Synonyms:3-(2-aminoethoxy)propanoic acid;144942-89-2;Amino-PEG1-acid;Amino-PEG1-C2-acid;3-(2-Aminoethoxy)propionic acid;Propanoic acid, 3-(2-aminoethoxy)-;Amine-PEG1-COOH;NH2-PEG1-COOH;6-amino-4-oxahexanoic acid;3-(2-aminoethoxy)propanoicacid;SCHEMBL2992343;AMY4548;ZCQVVSMJNBNDAQ-UHFFFAOYSA-N;3-(2-Amino-ethoxy)-propionic acid;MFCD22017475;ZB0981;AKOS022612351;SB75623;BP-20687;DS-12828;HY-140002;CS-0114519;C72750;EN300-208931

Chemical Property of 3-(2-Aminoethoxy)propanoic acid

Chemical Property:

• Boiling Point: 284.7±20.0 °C(Predicted)
• PKA: 4.17±0.10(Predicted)
• PSA: 0.00000
• Density: 1.150±0.06 g/cm3(Predicted)
• LogP: 0.00000
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Soluble in Water, DMSO, DMF
• XLogP3: -3.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 133.07389321
• Heavy Atom Count: 9
• Complexity: 84.3

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-(2-Aminoethoxy)propionicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C(COCCN)C(=O)O
• Description: Amino-PEG1-acid is a PEG linker containing an amino group (NH2) with a terminal carboxylic acid (CO2H). NH2 group is reactive with carboxylic acids in the presence of coupling reagent such as EDC , or directly with NHS esters, to form a stable amide bond.

Technology Process of 3-(2-Aminoethoxy)propanoic acid

There total 1 articles about 3-(2-Aminoethoxy)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2-tert-butoxycarbonylaminoethoxy)propionic acid tert-butyl ester → 3-(2-aminoethoxy)propionic acid (144942-89-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 30.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-(2-aminoethoxy)propionic acid (144942-89-2) → 3-(2-((tert-butoxycarbonyl)amino)ethoxy)propanoic acid (1260092-44-1)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; pH=8.5;

Reference yield:

maleic anhydride (108-31-6) + 3-(2-aminoethoxy)propionic acid (144942-89-2) → 3-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)propanoic acid (760952-64-5)

Guidance literature:

With acetic acid; at 120 ℃; for 6h;

DOI:10.3390/cancers12030744

Downstream raw materials:

3-(2-((tert-butoxycarbonyl)amino)ethoxy)propanoic acid

3-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)propanoic acid