t-Boc-N-amido-PEG1-acid

Base Information

• Chemical Name: t-Boc-N-amido-PEG1-acid
• CAS No.: 1260092-44-1
• Molecular Formula: C₁₀H₁₉NO₅
• Molecular Weight: 233.265
• Mol file: 1260092-44-1.mol

Synonyms:3-(2-((tert-butoxycarbonyl)amino)ethoxy)propanoic acid

Chemical Property of t-Boc-N-amido-PEG1-acid

Chemical Property:

• Boiling Point: 385.0±27.0 °C(Predicted)
• PKA: 4.29±0.10(Predicted)
• Density: 1.127±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Boc-NH-PEG1-CH2CH2COOH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: t-Boc-N-amido-PEG1-acid is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Technology Process of t-Boc-N-amido-PEG1-acid

There total 1 articles about t-Boc-N-amido-PEG1-acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-(2-aminoethoxy)propionic acid (144942-89-2) → 3-(2-((tert-butoxycarbonyl)amino)ethoxy)propanoic acid (1260092-44-1)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; pH=8.5;

Reference yield: 100.0%

3-(2-((tert-butoxycarbonyl)amino)ethoxy)propanoic acid (1260092-44-1) + O-benzylethanolamine (38336-04-8) → C19H30N2O5

Guidance literature:

3-(2-((tert-butoxycarbonyl)amino)ethoxy)propanoic acid; With benzotriazol-1-ol; HATU; In tetrahydrofuran; at 0 ℃; for 0.166667h;

O-benzylethanolamine; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield: 60.0%

3-(2-((tert-butoxycarbonyl)amino)ethoxy)propanoic acid (1260092-44-1) + N-(2-aminoethyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide dihydrochloride → C31H45N7O8

Guidance literature:

With O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 22 ℃; for 2h;

DOI:10.3390/molecules26102857

upstream raw materials:

di-tert-butyl dicarbonate

3-(2-aminoethoxy)propionic acid