2-(Benzyloxy)-2-methylpropanal

Base Information

• Chemical Name: 2-(Benzyloxy)-2-methylpropanal
• CAS No.: 145486-31-3
• Molecular Formula: C11H14O2
• Molecular Weight: 178.231
• European Community (EC) Number: 834-461-1
• Nikkaji Number: J981.343H
• Mol file: 145486-31-3.mol

Synonyms:2-(benzyloxy)-2-methylpropanal;145486-31-3;2-methyl-2-phenylmethoxypropanal;SCHEMBL9025685;JRXDMMPRRCEHHL-UHFFFAOYSA-N;2-Benzyloxy-2-methylpropionaldehyde;EN300-4410734;Z1511754920

Chemical Property of 2-(Benzyloxy)-2-methylpropanal

Chemical Property:

• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 178.099379685
• Heavy Atom Count: 13
• Complexity: 158

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(C=O)OCC1=CC=CC=C1

Technology Process of 2-(Benzyloxy)-2-methylpropanal

There total 4 articles about 2-(Benzyloxy)-2-methylpropanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-(benzyloxy)-2-methylpropan-1-ol (91968-71-7) → 2-(benzyloxy)-2-methylpropanal (145486-31-3)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

3-(benzyloxy)-3-methyl-1-butene (26902-24-9) → 2-(benzyloxy)-2-methylpropanal (145486-31-3)

Guidance literature:

With sodium periodate; osmium(VIII) oxide; In 1,4-dioxane; water;

Reference yield:

2-(benzyloxy)-2-methylpropanoic acid (87122-87-0) → 2-(benzyloxy)-2-methylpropanal (145486-31-3)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran / Heating

2: pyridinium chlorochlomate / CH₂Cl₂

With lithium aluminium tetrahydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo971803g

upstream raw materials:

2-(benzyloxy)-2-methylpropan-1-ol

2-(benzyloxy)-2-methylpropanoic acid

benzyl bromide

3-(benzyloxy)-3-methyl-1-butene

Downstream raw materials:

(S_S,E)-N-[2-(benzyloxy)-2-methylpropylidene]-2-methyl-2-propanesulfinamide