PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER

Base Information

• Chemical Name: PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER
• CAS No.: 145681-01-2
• Molecular Formula: C11H19NO4
• Molecular Weight: 229.276
• Hs Code.: 2933990090
• Mol file: 145681-01-2.mol

Synonyms:1-O-tert-butyl 2-O-methyl pyrrolidine-1,2-dicarboxylate;

Chemical Property of PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER

Chemical Property:

• Boiling Point: 288.6±33.0 °C(Predicted)
• PKA: -3.35±0.40(Predicted)
• PSA: 55.84000
• Density: 1.120±0.06 g/cm3(Predicted)
• LogP: 1.49680
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-tert-Butyl2-MethylPyrrolidine-1,2-dicarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER

There total 8 articles about PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-tert-butoxycarbonyl-proline (15761-39-4,59433-50-0) + methyl iodide (74-88-4) → (+/-)-N-tert-butoxycarbonylproline methyl ester (145681-01-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield: 95.0%

di-tert-butyl dicarbonate (24424-99-5) + methyl pyrrolidine-2-carboxylate hydrochloride (2133-40-6,65365-28-8,79397-50-5) → (+/-)-N-tert-butoxycarbonylproline methyl ester (145681-01-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h;

Reference yield: 95.0%

methyl iodide (74-88-4) → (+/-)-N-tert-butoxycarbonylproline methyl ester (145681-01-2)

Guidance literature:

N-tert-butoxycarbonyl-proline; With potassium carbonate; In N,N-dimethyl-formamide; for 0.833333h;

methyl iodide; In N,N-dimethyl-formamide; for 1h;

upstream raw materials:

di-tert-butyl dicarbonate

N-benzyloxycarbonylproline methyl ester

N-tert-butoxycarbonyl-proline

methyl iodide

Downstream raw materials:

(2R,5R)-1-(tert-butoxycarbonyl)-5-[(S)-methoxycarbonyl(4-bromophenyl)methyl]proline methyl ester

1-(tert-butoxycarbonyl)-L-proline

1-(tert-butyl) 2-methyl (R)-pyrrolidine-1,2-dicarboxylate

1-tert-butyl 2-methyl 2-(prop-2-en-1-yl)pyrrolidine-1,2-dicarboxylate

Refernces

• 1、 -. "Anti-tumor diazo dicyclic apoptosis protein inhibitor". Paragraph 0095-0098. . Retrieved 2019/08/01.
• 2、 Dong, Jianyang,Xia, Qing,Lv, Xueli,Yan, Changcun,Song, Hongjian,Liu, Yuxiu,Wang, Qingmin. "Photoredox-Mediated Direct Cross-Dehydrogenative Coupling of Heteroarenes and Amines". supporting information. p. 5661 - 5665. Retrieved 2018/09/21.