Mitoglitazone

Base Information

Chemical Name:Mitoglitazone
CAS No.:146062-49-9
Molecular Formula:C19H18N2O4S
Molecular Weight:370.42200
Hs Code.:
UNII:29I7RP18RG
DSSTox Substance ID:DTXSID301317736
Nikkaji Number:J730.386F
Wikidata:Q27166263
Metabolomics Workbench ID:152832
ChEMBL ID:CHEMBL146624
Mol file:146062-49-9.mol

Synonyms:MSDC-0160

Suppliers and Price of Mitoglitazone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
CAY10415
10mg
$ 185.00

Matrix Scientific
5-(4-(2-(5-Ethylpyridin-2-yl)-2-oxoethoxy)-benzyl)thiazolidine-2,4-dione 97%
1g
$ 6480.00

Matrix Scientific
5-(4-(2-(5-Ethylpyridin-2-yl)-2-oxoethoxy)-benzyl)thiazolidine-2,4-dione 97%
100mg
$ 2880.00

DC Chemicals
CAY10415(MSDC-0160) >98%
100 mg
$ 400.00

DC Chemicals
CAY10415(MSDC-0160) >98%
1 g
$ 1500.00

Crysdot
MSDC-0160 97%
100mg
$ 776.00

Crysdot
MSDC-0160 97%
50mg
$ 558.00

ChemScene
MSDC0160 99.40%
50mg
$ 250.00

ChemScene
MSDC0160 99.40%
2mg
$ 50.00

ChemScene
MSDC0160 99.40%
5mg
$ 80.00

Total 27 raw suppliers

Chemical Property of Mitoglitazone

Chemical Property:

Boiling Point:623.8±55.0 °C(Predicted)
PKA:6.32±0.50(Predicted)
PSA：114.15000
Density:1.315±0.06 g/cm3(Predicted)
LogP:3.07570
Storage Temp.:Sealed in dry,Store in freezer, under -20°C
Solubility.:≥37 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:370.09872823
Heavy Atom Count:26
Complexity:534

Purity/Quality:

99%, ^*data from raw suppliers

CAY10415 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1=CN=C(C=C1)C(=O)COC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
Recent ClinicalTrials:Study to Evaluate the Safety, Tolerability and Efficacy of Three Dose Levels of Mitoglitazone in Type 2 Diabetic Patients
Uses CAY10415 is used to study blood glucose levels and rates of insulin-stimulated lipogenesis.

Technology Process of Mitoglitazone

There total 23 articles about Mitoglitazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 101931-00-4
5-{4-[2-(5-ethyl-pyridin-2-yl)-2-hydroxyethoxy]benzyl}-2,4-thiazolidinedione

: 146062-49-9
rac-5-({p-[2-(5-ethylpyridin-2-yl)-2-oxoethoxy]phenyl}methyl)-1,3-thiazolidine-2,4-dione

Guidance literature:: With phosphorus pentoxide; dimethyl sulfoxide; triethylamine; In dichloromethane; for 2h;
DOI:10.1021/jm9605694

Reference yield: 70.0%

: 1359827-44-3
5-({4-[2-(5-ethyl-2-pyridinyl)-2-(methoxyimino)ethoxy]phenyl}methyl)-2,4-thiazolidinedione

: 146062-49-9
rac-5-({p-[2-(5-ethylpyridin-2-yl)-2-oxoethoxy]phenyl}methyl)-1,3-thiazolidine-2,4-dione

Guidance literature:: With hydrogenchloride; water; 2-oxo-propionic acid; at 75 ℃; for 2h;
DOI:10.1016/j.tetlet.2019.07.022

Reference yield:

: 1359827-43-2
2-bromo-1-(5-ethyl-2-pyridinyl)ethanone O-methyloxime

: 74772-78-4
5-(4-hydroxybenzyl)-2,4-thiazolidinedione

: 146062-49-9
rac-5-({p-[2-(5-ethylpyridin-2-yl)-2-oxoethoxy]phenyl}methyl)-1,3-thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.25 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: hydrogenchloride; water; 2-oxo-propionic acid / 2 h / 75 °C

With hydrogenchloride; potassium tert-butylate; water; 2-oxo-propionic acid; In dimethyl sulfoxide;
DOI:10.1016/j.tetlet.2019.07.022