Technology Process of 5-({4-[2-(5-ethyl-2-pyridinyl)-2-(methoxyimino)ethoxy]phenyl}methyl)-2,4-thiazolidinedione
There total 7 articles about 5-({4-[2-(5-ethyl-2-pyridinyl)-2-(methoxyimino)ethoxy]phenyl}methyl)-2,4-thiazolidinedione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-(4-hydroxybenzyl)-2,4-thiazolidinedione;
With
potassium tert-butylate;
In
dimethyl sulfoxide;
at 20 ℃;
for 0.25h;
Inert atmosphere;
2-bromo-1-(5-ethyl-2-pyridinyl)ethanone O-methyloxime;
In
dimethyl sulfoxide;
at 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1016/j.tetlet.2019.07.022
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / toluene; tetrahydrofuran / -40 °C
1.2: 20 °C
2.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,4-dioxane; hexane / 50 °C / Inert atmosphere
3.1: bromine; hydrogen bromide; acetic acid / 1 h / 10 - 20 °C
4.1: ethanol / 20 °C
5.1: potassium tert-butylate / dimethyl sulfoxide / 0.25 h / 20 °C
5.2: pH 3
With
n-butyllithium; potassium tert-butylate; hydrogen bromide; bromine; acetic acid;
palladium bis[bis(diphenylphosphino)ferrocene] dichloride;
In
tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dimethyl sulfoxide; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,4-dioxane; hexane / 50 °C / Inert atmosphere
2.1: bromine; hydrogen bromide; acetic acid / 1 h / 10 - 20 °C
3.1: ethanol / 20 °C
4.1: potassium tert-butylate / dimethyl sulfoxide / 0.25 h / 20 °C
4.2: pH 3
With
potassium tert-butylate; hydrogen bromide; bromine; acetic acid;
palladium bis[bis(diphenylphosphino)ferrocene] dichloride;
In
1,4-dioxane; ethanol; hexane; dimethyl sulfoxide;
