Benzenepropanoic acid, b-[tris(4-methylphenyl)germyl]-

Base Information

• Chemical Name: Benzenepropanoic acid, b-[tris(4-methylphenyl)germyl]-
• CAS No.: 146139-11-9
• Molecular Formula: C₃₀H₃₀GeO₂
• Molecular Weight: 495.157
• Mol file: 146139-11-9.mol

Synonyms:

Chemical Property of Benzenepropanoic acid, b-[tris(4-methylphenyl)germyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenepropanoic acid, b-[tris(4-methylphenyl)germyl]-

There total 1 articles about Benzenepropanoic acid, b-[tris(4-methylphenyl)germyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-phenyl-3-(trichlorogermyl)butanoic acid + para-methylphenylmagnesium bromide (4294-57-9) → (p-CH3C6H4)3GeCH(C6H5)CH2COOH (146139-11-9)

Guidance literature:

In tetrahydrofuran; Mg-compd. added dropwise at 0°C to Ge-compd. in THF, refluxed for4 h, cooled; 10% aq. HCl added, extracted with CHCl3, CHCl3 phase dried over anhydrous MgSO4, filtered, solv. removed in vac., recrystallised from CHCl3 and acetone (3:1);

DOI:10.1080/15533170701301470

Reference yield: 85.0%

(p-CH3C6H4)3GeCH(C6H5)CH2COOH (146139-11-9) + triphenylantimony dibromide (20265-30-9) → [(p-CH3C6H4)3GeCHPhCH2COO]2(antimony)Ph3 (945655-66-3)

Guidance literature:

With NEt₃; In toluene; byproducts: Et3N*HCl; according to reported method: Ma, Y.Q., Li, J.S. Main Group Met. Chem. 2001, 24, 235-238.; crystd. from CH2Cl2/petroleum ether; elem. anal.;

DOI:10.1080/15533170600862903

Reference yield: 83.0%

(p-CH3C6H4)3GeCH(C6H5)CH2COOH (146139-11-9) + trimethyltin(IV)chloride (1066-45-1) → trimethyltin(IV)-3-(tri-p-tolylgermyl)-3-phenylpropionate (1012061-72-1)

Guidance literature:

With triethylamine; In toluene; byproducts: Et3N*HCl; equimolar of Ge-compd. and (CH3)3SnCl refluxed for 8-10 h in toluene in the presence of Et3N, cooled; filtered, solv. removed in vac., recrystallized from CHCl3 and acetone (3:1), elem. anal.;

DOI:10.1080/15533170701301470

upstream raw materials:

para-methylphenylmagnesium bromide

Downstream raw materials:

[(p-CH₃C₆H₄)3GeCHPhCH₂COO]2(antimony)Ph₃

trimethyltin(IV)-3-(tri-p-tolylgermyl)-3-phenylpropionate