(6Z)-5-[(4-chlorophenyl)hydrazono]-6-imino-1,3-dimethyldihydropyrimidine-2,4(1H,3H)-dione

Base Information

• Chemical Name: (6Z)-5-[(4-chlorophenyl)hydrazono]-6-imino-1,3-dimethyldihydropyrimidine-2,4(1H,3H)-dione
• CAS No.: 63351-22-4
• Molecular Formula: C12H12 Cl N5 O2
• Molecular Weight: 293.713
• Mol file: 63351-22-4.mol

Synonyms:2,4(1H,3H)-Pyrimidinedione,6-amino-5-[(4-chlorophenyl)azo]-1,3-dimethyl- (9CI); NSC 39256

Chemical Property of (6Z)-5-[(4-chlorophenyl)hydrazono]-6-imino-1,3-dimethyldihydropyrimidine-2,4(1H,3H)-dione

Chemical Property:

• Vapor Pressure: 4.86E-06mmHg at 25°C
• Boiling Point: 382°Cat760mmHg
• Flash Point: 184.8°C
• Density: 1.47g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (6Z)-5-[(4-chlorophenyl)hydrazono]-6-imino-1,3-dimethyldihydropyrimidine-2,4(1H,3H)-dione

There total 1 articles about (6Z)-5-[(4-chlorophenyl)hydrazono]-6-imino-1,3-dimethyldihydropyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

6-Amino-1,3-dimethylbarbituric acid (6642-31-5) + 4-chloro-aniline (106-47-8) → 6-amino-1,3-dimethyl-5-[(4-chlorophenyl)diazenyl]uracil (63351-22-4)

Guidance literature:

4-chloro-aniline; With sulfuric acid; acetic acid; sodium nitrite; at 0 - 5 ℃; for 2h;

6-Amino-1,3-dimethylbarbituric acid; With sodium hydroxide; In water; at 0 - 5 ℃; for 0.333333h; pH=7;

DOI:10.1016/j.molstruc.2010.06.005

Reference yield: 79.0%

nickel(II) chloride hexahydrate + 6-amino-1,3-dimethyl-5-[(4-chlorophenyl)diazenyl]uracil (63351-22-4) → bis[1,3-dimethyl-5-(p-chlorophenylazo)-6-aminouracilato]nickel(II)

Guidance literature:

With sodium hydrogencarbonate; In water; N,N-dimethyl-formamide; at 110 ℃; for 2h;

DOI:10.1002/ejic.201601021

Reference yield: 65.0%

6-amino-1,3-dimethyl-5-[(4-chlorophenyl)diazenyl]uracil (63351-22-4) → 1,3-dimethyl-5-(p-chlorophenylazo)barbituric acid (30201-40-2)

Guidance literature:

With hydrogenchloride; water; for 4h; Reflux;

DOI:10.1002/jccs.201600007

upstream raw materials:

6-Amino-1,3-dimethylbarbituric acid

4-chloro-aniline

Downstream raw materials:

2-(4-Chloro-phenyl)-5,7-dimethyl-2H,5H-pyrimido[4,5-e][1,2,4]triazine-3,6,8-trione

(Z)-3-[5-(4-Chloro-phenylazo)-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-ylamino]-acrylic acid ethyl ester

2-(4-Chloro-phenyl)-4-methyl-2H-[1,2,4]triazine-3,5-dione

8-[(4-Chloro-phenylamino)-methyl]-1,3-dimethyl-3,7-dihydro-purine-2,6-dione