N-p-tolylbiphenyl-4-amine

Base Information

• Chemical Name: N-p-tolylbiphenyl-4-amine
• CAS No.: 147678-90-8
• Molecular Formula: C19H17N
• Molecular Weight: 259.351
• Hs Code.: 2921499090
• DSSTox Substance ID: DTXSID50396703
• Nikkaji Number: J778.182B
• Wikidata: Q82197556
• Mol file: 147678-90-8.mol

Synonyms:147678-90-8;N-p-tolylbiphenyl-4-amine;N-(p-Tolyl)-[1,1'-biphenyl]-4-amine;4-methyl-N-(4-phenylphenyl)aniline;[1,1'-Biphenyl]-4-amine, N-(4-methylphenyl)-;SCHEMBL401617;DTXSID50396703;N-p-Tolyl-1,1'-biphenyl-4-amine;AKOS015917922;SB81986;N-(p-Tolyl)-[1,1/'-biphenyl]-4-aMine;FT-0710671;A853230

Chemical Property of N-p-tolylbiphenyl-4-amine

Chemical Property:

• Vapor Pressure: 1.57E-07mmHg at 25°C
• Boiling Point: 428oC at 760 mmHg
• Flash Point: 228.3oC
• PSA: 12.03000
• LogP: 5.47860
• Storage Temp.: 2-8°C
• XLogP3: 6.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 259.136099547
• Heavy Atom Count: 20
• Complexity: 266

Purity/Quality:

97% ^*data from raw suppliers

N-(p-Tolyl)-[1,1'-biphenyl]-4-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)NC2=CC=C(C=C2)C3=CC=CC=C3

Technology Process of N-p-tolylbiphenyl-4-amine

There total 13 articles about N-p-tolylbiphenyl-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-phenyl-4-nitrobenzene (92-93-3) + p-toluidine (106-49-0,12221-03-3) → N-(4-(methyl)phenyl)-[1,1′-biphenyl]-4-amine (147678-90-8)

Guidance literature:

With bis(acetylacetonato)palladium(II); potassium phosphate tribasic trihydrate; 2-(2,6-diethyl-4-methylphenyl)-5-(2,4,6-triisopropylphenyl)imidazo[1,5-a]pyridin-2-ium chloride; In 1,4-dioxane; at 130 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acscatal.9b02760

Reference yield: 98.0%

tri-p-cresyl phosphate (78-32-0) + 4-phenylalanine (92-67-1) → N-(4-(methyl)phenyl)-[1,1′-biphenyl]-4-amine (147678-90-8)

Guidance literature:

With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; N-[2-(di(1-adamantyl)phosphino)phenyl]morpholine; potassium carbonate; at 130 ℃; for 4h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.9b00703

Reference yield: 93.0%

2-([1,1′-biphenyl]-4-yloxy)pyridine (28355-52-4) + p-toluidine (106-49-0,12221-03-3) → N-(4-(methyl)phenyl)-[1,1′-biphenyl]-4-amine (147678-90-8)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; sodium t-butanolate; 1,3-bis[2,6-bis(1-methylethyl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene monohydrochloride; In 1,4-dioxane; at 100 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.7b01549

upstream raw materials:

4-tolyl iodide

4-phenylalanine

biphenyl

N-(4-methylphenyl)hydroxylamine