Carbamic acid, [(1S,2S,4R)-5-[[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]amino]-2- [[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-oxo-1,4-bis(phenylmethyl)pentyl]- , 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [(1S,2S,4R)-5-[[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]amino]-2- [[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-oxo-1,4-bis(phenylmethyl)pentyl]- , 1,1-dimethylethyl ester
CAS No.:147912-04-7
Molecular Formula:C39H54N2O5Si
Molecular Weight:658.954
Hs Code.:
Mol file:147912-04-7.mol

Carbamic acid,
[(1S,2S,4R)-5-[[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]amino]-2-
[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-oxo-1,4-bis(phenylmethyl)pentyl]-
, 1,1-dimethylethyl ester

Synonyms:

Suppliers and Price of Carbamic acid, [(1S,2S,4R)-5-[[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]amino]-2- [[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-oxo-1,4-bis(phenylmethyl)pentyl]- , 1,1-dimethylethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbamic acid, [(1S,2S,4R)-5-[[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]amino]-2- [[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-oxo-1,4-bis(phenylmethyl)pentyl]- , 1,1-dimethylethyl ester

Chemical Property:

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Hazard Codes:

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Technology Process of Carbamic acid, [(1S,2S,4R)-5-[[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]amino]-2- [[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-oxo-1,4-bis(phenylmethyl)pentyl]- , 1,1-dimethylethyl ester

There total 19 articles about Carbamic acid, [(1S,2S,4R)-5-[[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]amino]-2- [[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-oxo-1,4-bis(phenylmethyl)pentyl]- , 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 98818-51-0
N-(1,1-dimethylethoxycarbonyl)-5(S)-amino-4(S)-(t-butyldimethylsilyloxy)-6-phenyl-2(R)-(phenylmethyl)hexanoic acid

: 7480-35-5,13286-59-4,74165-73-4,126456-43-7,136030-00-7,140632-19-5,140632-20-8
(1S,2R)-1-amino-2-indanol

: 147912-04-7
[(1S,2S,4R)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-4-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-carbamic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 15h;
DOI:10.1055/s-2003-37649

Reference yield:

: 63516-03-0
α-bromo-p-toluidine

: 147912-04-7
[(1S,2S,4R)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-4-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: NaOEt / ethanol / 18 h / Ambient temperature

2: aq. LiOH / ethanol / 5 h

3: toluene / 24 h / Heating

4: aq. LiOH / 1,2-dimethoxy-ethane / 3 h / Ambient temperature

5: 1.) imidazole / 1.) DMF, RT, 24 h, 2.) DMF, MeOH, RT, 4 h

6: EDC*HCl, HOBt, Et₃N / dimethylformamide / 20 h / Ambient temperature

With 1H-imidazole; lithium hydroxide; sodium ethanolate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00088a004

Reference yield:

: 193338-94-2
(5S,1'S)-carbetoxy-5-<1-<<(1',1-dimethylothoxy)carbonyl>amino>-2-phenylmethyl>dihydrofuran-2(3H)-one

: 147912-04-7
[(1S,2S,4R)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-4-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: NaOEt / ethanol / 18 h / Ambient temperature

2: aq. LiOH / ethanol / 5 h

3: toluene / 24 h / Heating

4: aq. LiOH / 1,2-dimethoxy-ethane / 3 h / Ambient temperature

5: 1.) imidazole / 1.) DMF, RT, 24 h, 2.) DMF, MeOH, RT, 4 h

6: EDC*HCl, HOBt, Et₃N / dimethylformamide / 20 h / Ambient temperature

With 1H-imidazole; lithium hydroxide; sodium ethanolate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00088a004