193338-94-2

Basic information

• Product Name: (5S,1'S)-carbetoxy-5-<1-<<(1',1-dimethylothoxy)carbonyl>amino>-2-phenylmethyl>dihydrofuran-2(3H)-one
• Synonyms: (5S,1'S)-carbetoxy-5-<1-<<(1',1-dimethylothoxy)carbonyl>amino>-2-phenylmethyl>dihydrofuran-2(3H)-one
• CAS NO: 193338-94-2
• Molecular Weight: 377.437
• Mol File: 193338-94-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (5S,1'S)-carbetoxy-5-<1-<<(1',1-dimethylothoxy)carbonyl>amino>-2-phenylmethyl>dihydrofuran-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (5S,1'S)-carbetoxy-5-<1-<<(1',1-dimethylothoxy)carbonyl>amino>-2-phenylmethyl>dihydrofuran-2(3H)-one(193338-94-2)
• EPA Substance Registry System: (5S,1'S)-carbetoxy-5-<1-<<(1',1-dimethylothoxy)carbonyl>amino>-2-phenylmethyl>dihydrofuran-2(3H)-one(193338-94-2)

Safety Data

• Hazardous Substances Data: 193338-94-2(Hazardous Substances Data)

Upstream product

• 220871-52-3 1(R,S)-<1'-(S)-<(tert-butyloxycarbonyl)amino>-2-phenylethyl>oxirane 
• 105-53-3 diethyl malonate 
• 98760-08-8 (2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane 

Downstream Products

• 126410-41-1 3-carbethoxy-3-<<4-(benzyloxy)phenyl>methyl>-5(S)-<1'-(S)-<(tert-butyloxycarbonyl)amino>-2-phenylethyl>dihydrofuran-2(3H)-one 
• 905836-52-4 (S)-5-((S)-1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-2-oxo-3-(4-pyridin-2-yl-benzyl)-tetrahydro-furan-3-carboxylic acid ethyl ester 
• 193339-06-9 (4S,5S)-5-<1-(t-Boc-amino)-2-phenylethyl>-3-carbethoxy-3-(phenylmethyl)dihydrofuran-2(3H)-one 

Relevant articles and documents

An efficient, stereoselective synthesis of the hydroxyethylene dipeptide isostere core for the HIV protease inhibitor A-792611

A stereoselective synthesis of the hydroxyethylene dipeptide isostere 1 is described. The route employs a substrate-directed kinetic protonation of an α/γ-substituted lactone to afford the desired stereochemistry. A method for converting the diastereomeri

Process for the preparation of a substituted diaminoalcohol

A process is disclosed for the preparation of a substituted diaminoalcohol of the formula: STR1

Inhibitors of HIV protease

A dipeptide isostere is the biotransformed product after incubation with a culture of Streptomyces. It inhibits HIV protease, and is useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as a compound, pharmaceutically acceptable salt, pharmaceutical composition ingredient, whether or not as a prodrug or as a combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.