3-Hydroxyproline

Base Information Edit

Chemical Name:3-Hydroxyproline
CAS No.:14916-76-8
Molecular Formula:C5H9NO3
Molecular Weight:131.131
Hs Code.:
DSSTox Substance ID:DTXSID20276427
Nikkaji Number:J413.965H
Wikidata:Q27109279
Mol file:14916-76-8.mol

Synonyms:3-hydroxyproline;3-hydroxyproline, (L)-isomer;3-hydroxyproline, DL-(cis)-isomer;3-hydroxyproline, DL-(trans)-isomer;3-hydroxyproline, L-(cis)-isomer;3-hydroxyproline, L-(trans)-isomer

Suppliers and Price of 3-Hydroxyproline

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 3-Hydroxyproline Edit

Chemical Property:

XLogP3:-3.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:131.058243149
Heavy Atom Count:9
Complexity:125

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNC(C1O)C(=O)O
Isomeric SMILES:C1CN[C@@H](C1O)C(=O)O

Technology Process of 3-Hydroxyproline

There total 31 articles about 3-Hydroxyproline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 567-35-1,567-36-2,4298-05-9,4298-06-0,4298-08-2,14916-76-8,62182-84-7,104069-26-3,118492-86-7,119677-21-3
(2S,3R)-3-hydroxyproline

Guidance literature:: With ferrous(II) sulfate heptahydrate; cis-3-proline hydroxylase type II; sodium L-ascorbate; at 37 ℃; for 16h; stereospecific reaction;
DOI:10.3762/bjoc.7.193

Reference yield: 98.0%

: 1262015-07-5
(2S,3R)-N-(benzyloxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acid

: 567-35-1,567-36-2,4298-05-9,4298-06-0,4298-08-2,14916-76-8,62182-84-7,104069-26-3,118492-86-7,119677-21-3
(2S,3R)-3-hydroxyproline

Guidance literature:: With hydrogen; palladium(II) hydroxide; In methanol; at 25 ℃; for 12h; under 4137.29 Torr;
DOI:10.1016/j.tetlet.2010.10.086

Reference yield: 90.0%

: 166383-67-1
(2S,3R)-1-(tert-butoxycarbonyl)-3-(tert-butyldimethylsiloxy)pyrrolidine-2-carboxylic acid

: 567-35-1,567-36-2,4298-05-9,4298-06-0,4298-08-2,14916-76-8,62182-84-7,104069-26-3,118492-86-7,119677-21-3
(2S,3R)-3-hydroxyproline

Guidance literature:: (2S,3R)-1-(tert-butoxycarbonyl)-3-(tert-butyldimethylsiloxy)pyrrolidine-2-carboxylic acid; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h;

With methyloxirane; In methanol; at 20 ℃; for 2h;