2H-1-Benzazepin-2-one,1,3,4,5-tetrahydro-3-hydroxy-4-(4-methoxyphenyl)-6-(trifluoromethyl)-, (3S,4R)-

Base Information

Chemical Name:2H-1-Benzazepin-2-one,1,3,4,5-tetrahydro-3-hydroxy-4-(4-methoxyphenyl)-6-(trifluoromethyl)-, (3S,4R)-
CAS No.:127061-45-4
Molecular Formula:C₁₈H₁₆F₃NO₃
Molecular Weight:351.325
Hs Code.:

Synonyms:2H-1-Benzazepin-2-one,1,3,4,5-tetrahydro-3-hydroxy-4-(4-methoxyphenyl)-6-(trifluoromethyl)-,(3S-cis)-; SQ 32192

Suppliers and Price of 2H-1-Benzazepin-2-one,1,3,4,5-tetrahydro-3-hydroxy-4-(4-methoxyphenyl)-6-(trifluoromethyl)-, (3S,4R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2H-1-Benzazepin-2-one,1,3,4,5-tetrahydro-3-hydroxy-4-(4-methoxyphenyl)-6-(trifluoromethyl)-, (3S,4R)-

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2H-1-Benzazepin-2-one,1,3,4,5-tetrahydro-3-hydroxy-4-(4-methoxyphenyl)-6-(trifluoromethyl)-, (3S,4R)-

There total 13 articles about 2H-1-Benzazepin-2-one,1,3,4,5-tetrahydro-3-hydroxy-4-(4-methoxyphenyl)-6-(trifluoromethyl)-, (3S,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 138337-24-3,138383-38-7,145681-71-6
(3R,4R)-3-Hydroxy-4-(4-methoxy-phenyl)-2-oxo-6-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepine-3-carboxylic acid methyl ester

: 126958-67-6,127061-43-2,127061-45-4,133963-42-5,137821-01-3,138383-39-8
(3S,4S)-3-Hydroxy-4-(4-methoxy-phenyl)-6-trifluoromethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one

: 133963-42-5
(3R,4S)-3-Hydroxy-4-(4-methoxy-phenyl)-6-trifluoromethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one

Guidance literature:: With water; lithium iodide; In pyridine; Title compound not separated from byproducts; Heating;
DOI:10.1021/jm00082a018

Reference yield: 66.0%

: 138337-24-3
(3S,4S)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-hydroxy-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

: 126958-67-6,127061-43-2,127061-45-4,133963-42-5,137821-01-3,138383-39-8
(3S,4S-trans)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-hydroxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

: 127061-43-2
(3R-cis)-3-(hydroxy)-1,3,4,5-tetrahydro-4-[4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one

Guidance literature:: With water; lithium iodide; In pyridine; for 2h; Heating;
DOI:10.1021/jm00082a018

Reference yield:

: 6656-49-1
2-methyl-1-nitro-3-(trifluoromethyl)benzene

: 126958-67-6,127061-43-2,127061-45-4,133963-42-5,137821-01-3,138383-39-8
(3S,4S)-3-Hydroxy-4-(4-methoxy-phenyl)-6-trifluoromethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / NaH / dimethylformamide / 20 h / 28 - 30 °C

2: 95 percent / H₂ / 5percent Pd/C / methanol

3: 97 percent / NaOMe / methanol / Heating

4: O₂, potassium hexamethyldisilazide, P(OEt)3 / tetrahydrofuran

5: LiI / pyridine; H₂O / 100 °C

With hydrogen; oxygen; sodium methylate; potassium hexamethylsilazane; sodium hydride; lithium iodide; triethyl phosphite; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; water; N,N-dimethyl-formamide;