(3S,4S-trans)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

Base Information

• Chemical Name: (3S,4S-trans)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one
• CAS No.: 111605-09-5
• Molecular Formula: C₂₀H₁₈F₃NO₄
• Molecular Weight: 393.362

Synonyms:(3S,4S-trans)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

Chemical Property of (3S,4S-trans)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

Chemical Property:

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Technology Process of (3S,4S-trans)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

There total 5 articles about (3S,4S-trans)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(3S,4S-trans)-3-carboxy-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one (S)-α-methylbenzylamine salt (111688-58-5) + methyl iodide (74-88-4) → (3S,4S-trans)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one (111605-09-5)

Guidance literature:

With potassium hydrogencarbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 5.16667h;

DOI:10.1021/jm00082a018

Reference yield: 74.0%

(R)-4-(2-Amino-6-trifluoromethyl-phenyl)-2-[((1R,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-3-(4-methoxy-phenyl)-butyric acid methyl ester → (3S,4S-trans)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one (111605-09-5)

Guidance literature:

With thionyl chloride; In 1,2-dichloro-ethane; Ambient temperature;

DOI:10.1016/S0040-4039(00)73443-5

Reference yield:

(3R,4R-trans)-3-carboxy-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one (R)-α-methylbenzylamine salt (111688-58-5) + methyl iodide (74-88-4) → (3R,4R-trans)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one (111605-06-2,111605-09-5,138383-10-5)

Guidance literature:

With potassium hydrogencarbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 5.16667h;

DOI:10.1021/jm00082a018

upstream raw materials:

(3R,4R-trans)-3-carboxy-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one (R)-α-methylbenzylamine salt

methyl iodide

(3S,4S-trans)-3-carboxy-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one (S)-α-methylbenzylamine salt

Downstream raw materials:

(3R,4R)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-hydroxy-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

(3S,4R-cis)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-hydroxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

(3R,4R-trans)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-hydroxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

(3S,4R-cis)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-hydroxy-1-<2-(dimethylamino)ethyl>-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

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