1,2-Pyrrolidinedicarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, 1-(1,1-dimethylethyl) ester, (2S,4R)-

Base Information

Chemical Name:1,2-Pyrrolidinedicarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, 1-(1,1-dimethylethyl) ester, (2S,4R)-
CAS No.:149814-40-4
Molecular Formula:C16H31NO5Si
Molecular Weight:345.511
Hs Code.:

Synonyms:N-Boc-trans-4-tert-butyldimethylsiloxy-L-proline;

Suppliers and Price of 1,2-Pyrrolidinedicarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, 1-(1,1-dimethylethyl) ester, (2S,4R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
(2S,4R)-1-(tert-Butoxycarbonyl)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylicacid
5g
$ 1497.00

ChemScene
(2S,4R)-1-(tert-Butoxycarbonyl)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylicacid
1g
$ 499.00

American Custom Chemicals Corporation
(2S,4R)-1-(TERT-BUTOXYCARBONYL)-4-(TERT-BUTYLDIMETHYLSILYLOXY)PYRROLIDINE-2-CARBOXYLIC ACID 95.00%
5MG
$ 505.45

Abosyn
(2S,4R)-1-(tert-butoxycarbonyl)-4-(tert-butyldimethylsilyloxy)pyrrolidine-2-carboxylicacid 95%-98%
1g
$ 785.00

Total 3 raw suppliers

Chemical Property of 1,2-Pyrrolidinedicarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, 1-(1,1-dimethylethyl) ester, (2S,4R)-

Chemical Property:

PSA：76.07000
LogP:3.40870

Purity/Quality:

97% ^*data from raw suppliers

(2S,4R)-1-(tert-Butoxycarbonyl)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1,2-Pyrrolidinedicarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, 1-(1,1-dimethylethyl) ester, (2S,4R)-

There total 9 articles about 1,2-Pyrrolidinedicarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, 1-(1,1-dimethylethyl) ester, (2S,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 114676-91-4
1-tert-butyl 2-methyl (2S,4R)-4-{[tert-butyl(dimethyl)silyl]oxy}pyrrolidine-1,2-dicarboxylate

: 149814-40-4
(2S,4R)-1-(tert-butoxycarbonyl)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylic acid

Guidance literature:: With lithium hydroxide; In methanol; at 45 ℃; for 1h;
DOI:10.1039/b105238c

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 149814-40-4
(2S,4R)-1-(tert-butoxycarbonyl)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / Et₃N; DMAP / CH₂Cl₂ / 20 °C

2: 100 percent / imidazole / dimethylformamide / 20 °C

3: 96 percent / aq. LiOH / methanol / 1 h / 45 °C

With 1H-imidazole; dmap; lithium hydroxide; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b105238c