Carbamic acid, [(1S)-1-[(2S,4R)-4-[(4-fluorophenyl)methyl]tetrahydro-5-oxo-2-furanyl]-2- phenylethyl]-, 1,1-dimethylethyl ester

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Chemical Name:Carbamic acid, [(1S)-1-[(2S,4R)-4-[(4-fluorophenyl)methyl]tetrahydro-5-oxo-2-furanyl]-2- phenylethyl]-, 1,1-dimethylethyl ester
CAS No.:150609-73-7
Molecular Formula:C24H28FNO4
Molecular Weight:413.489
Hs Code.:
Mol file:150609-73-7.mol

Synonyms:

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Chemical Property of Carbamic acid, [(1S)-1-[(2S,4R)-4-[(4-fluorophenyl)methyl]tetrahydro-5-oxo-2-furanyl]-2- phenylethyl]-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [(1S)-1-[(2S,4R)-4-[(4-fluorophenyl)methyl]tetrahydro-5-oxo-2-furanyl]-2- phenylethyl]-, 1,1-dimethylethyl ester

There total 9 articles about Carbamic acid, [(1S)-1-[(2S,4R)-4-[(4-fluorophenyl)methyl]tetrahydro-5-oxo-2-furanyl]-2- phenylethyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 223520-70-5
[1-benzyl-5-(2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-4-(4-fluoro-benzyl)-2-hydroxy-5-oxo-pentyl]-carbamic acid tert-butyl ester

: 150609-73-7
(1S,2'S,4'R)-<1-<4'-(4''-fluorobenzyl)-5'-oxo-tetrahydrofuran-2'-yl>-2-phenylethyl>carbamic acid tert-butyl ester

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane; toluene; at 23 ℃; for 13h;
DOI:10.1021/jm980537b

Reference yield:

: 459-31-4
3-(4-fluorophenyl)propanoic acid

: 150609-73-7
(1S,2'S,4'R)-<1-<4'-(4''-fluorobenzyl)-5'-oxo-tetrahydrofuran-2'-yl>-2-phenylethyl>carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl chloride / dimethylformamide; benzene / 1.5 h / 23 °C

2: Et₃N / tetrahydrofuran / 0.33 h / 0 °C

3: methanesulfonic acid / CH₂Cl₂ / 0.25 h / 23 °C

4: 49 percent / n-BuLi / tetrahydrofuran; hexane / a) -78 deg C, 5 min, b) 0 deg C, 1 h

5: 59 percent / p-TsOH*H₂O / CH₂Cl₂; toluene / 13 h / 23 °C

With n-butyllithium; oxalyl dichloride; methanesulfonic acid; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/jm980537b

Reference yield:

: 772-70-3
3-(4-fluorophenyl)propanoyl chloride

: 150609-73-7
(1S,2'S,4'R)-<1-<4'-(4''-fluorobenzyl)-5'-oxo-tetrahydrofuran-2'-yl>-2-phenylethyl>carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / tetrahydrofuran / 0.33 h / 0 °C

2: methanesulfonic acid / CH₂Cl₂ / 0.25 h / 23 °C

3: 49 percent / n-BuLi / tetrahydrofuran; hexane / a) -78 deg C, 5 min, b) 0 deg C, 1 h

4: 59 percent / p-TsOH*H₂O / CH₂Cl₂; toluene / 13 h / 23 °C

With n-butyllithium; methanesulfonic acid; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1021/jm980537b