2-Thiophenesulfonamide, 3-[4-[(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]- 5-(2-methylpropyl)-

Base Information

Chemical Name:2-Thiophenesulfonamide, 3-[4-[(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]- 5-(2-methylpropyl)-
CAS No.:151467-40-2
Molecular Formula:C25H30N4O2S2
Molecular Weight:482.671
Hs Code.:
Mol file:151467-40-2.mol

Synonyms:

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Chemical Property of 2-Thiophenesulfonamide, 3-[4-[(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]- 5-(2-methylpropyl)-

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Technology Process of 2-Thiophenesulfonamide, 3-[4-[(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]- 5-(2-methylpropyl)-

There total 3 articles about 2-Thiophenesulfonamide, 3-[4-[(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]- 5-(2-methylpropyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 151467-35-5
5,7-dimethyl-2-ethyl-3-[[4-[2-(N-t-butylaminosulfonyl)-5-iso-butyl-3-thienyl]phenyl]methyl]-imidazo[4,5-b ]pyridine

: 151467-40-2
3-[4-(2-ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-phenyl]-5-isobutyl-thiophene-2-sulfonic acid amide

Guidance literature:: With boron trichloride; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1016/S0040-4039(03)01020-7

Reference yield:

: 154553-72-7
2-ethyl-5,7-dimethyl-3-(4-bromobenzyl)imidazo<4,5-b>pyridine

: 151467-40-2
3-[4-(2-ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-phenyl]-5-isobutyl-thiophene-2-sulfonic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1: [Pd(PPh₃)4]; NaOH / ethanol; toluene; H₂O

2: TFA; anisole

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; methoxybenzene; trifluoroacetic acid; In ethanol; water; toluene; 1: Suzuki coupling;
DOI:10.1021/jm031031i

Reference yield:

: 163520-14-7
5-isobutyl-2 -(tert-butylaminosulfonyl)-3-thiopheneboronic acid

: 151467-40-2
3-[4-(2-ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-phenyl]-5-isobutyl-thiophene-2-sulfonic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1: [Pd(PPh₃)4]; NaOH / ethanol; toluene; H₂O

2: TFA; anisole

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; methoxybenzene; trifluoroacetic acid; In ethanol; water; toluene; 1: Suzuki coupling;
DOI:10.1021/jm031031i