1H-Pyrazole-5-carboxylic acid, 3-butyl-1-(2-pyridinyl)-4-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, ethyl ester

Base Information

Chemical Name:1H-Pyrazole-5-carboxylic acid, 3-butyl-1-(2-pyridinyl)-4-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, ethyl ester
CAS No.:152713-36-5
Molecular Formula:C29H29N7O2
Molecular Weight:507.595
Hs Code.:
Mol file:152713-36-5.mol

Synonyms:

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Chemical Property of 1H-Pyrazole-5-carboxylic acid, 3-butyl-1-(2-pyridinyl)-4-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, ethyl ester

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Technology Process of 1H-Pyrazole-5-carboxylic acid, 3-butyl-1-(2-pyridinyl)-4-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, ethyl ester

There total 4 articles about 1H-Pyrazole-5-carboxylic acid, 3-butyl-1-(2-pyridinyl)-4-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114772-54-2
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

: 152713-36-5
5-Butyl-2-pyridin-2-yl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2H-pyrazole-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 56 percent / K₂CO₃ / dimethylformamide / 24 h / Ambient temperature

2: 69 percent / acetic acid; 2-methoxy-ethanol / 45 h / 105 °C

3: 1.) trimethyltin azide, 2.) silica gel / 1.) toluene, reflux, 54 h, 2.) MeOH, RT, 2 h

With trimethyltin azide; silica gel; potassium carbonate; In 2-methoxy-ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00075a014

Reference yield:

: 138733-41-2
ethyl 2-(methoxyimino)-4-oxooctanoate

: 152713-36-5
5-Butyl-2-pyridin-2-yl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2H-pyrazole-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 56 percent / K₂CO₃ / dimethylformamide / 24 h / Ambient temperature

2: 69 percent / acetic acid; 2-methoxy-ethanol / 45 h / 105 °C

3: 1.) trimethyltin azide, 2.) silica gel / 1.) toluene, reflux, 54 h, 2.) MeOH, RT, 2 h

With trimethyltin azide; silica gel; potassium carbonate; In 2-methoxy-ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00075a014

Reference yield:

: 138733-42-3
ethyl 3-<(2'-cyanobiphenyl-4-yl)methyl>-2-(methoxyimino)-4-oxooctanoate

: 152713-36-5
5-Butyl-2-pyridin-2-yl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2H-pyrazole-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / acetic acid; 2-methoxy-ethanol / 45 h / 105 °C

2: 1.) trimethyltin azide, 2.) silica gel / 1.) toluene, reflux, 54 h, 2.) MeOH, RT, 2 h

With trimethyltin azide; silica gel; In 2-methoxy-ethanol; acetic acid;
DOI:10.1021/jm00075a014