Welcome to LookChem.com Sign In|Join Free
  • or

114772-54-2

Post Buying Request

114772-54-2 Suppliers

Recommended suppliersmore

Product FOB Price Min.Order Supply Ability Supplier
Factory direct sales, quality assurance. 4-Bromomethyl-2-cyanobiphenyl
Cas No: 114772-54-2
No Data No Data 20 Metric Ton/Year Tianjin Security Technology Development Co. Ltd. Contact Supplier
Br-OTBN
Cas No: 114772-54-2
No Data No Data No Data Ningbo Zhenlei Chemical Co.,ltd. Contact Supplier
4-Bromomethyl-2-cyanobiphenyl Manufacturer/High quality/Best price/In stock
Cas No: 114772-54-2
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High quality 2-Cyano-4-Bromomethyl Biphenyl supplier in China
Cas No: 114772-54-2
No Data 1 Metric Ton 30 Metric Ton/Month Simagchem Corporation Contact Supplier
High purity Various Specifications 4'-bromomethyl-2-cyanobiphenyl CAS:114772-54-2
Cas No: 114772-54-2
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
4-Bromomethyl-2-cyanobiphenyl Manufacturer/High quality/Best price/In stock CAS NO.114772-54-2
Cas No: 114772-54-2
USD $ 1.0-3.0 / Kilogram 1 Kilogram 10 Kilogram/Day Hebei yanxi chemical co.,LTD. Contact Supplier
114772-54-24-Bromomethyl-2-cyanobiphenyl
Cas No: 114772-54-2
No Data 1 Kilogram 20 Metric Ton/Day Henan Allgreen Chemical Co.,Ltd Contact Supplier
114772-54-2 [1,1'-Biphenyl]-2-carbonitrile,4'-(bromomethyl)-
Cas No: 114772-54-2
USD $ 40.0-50.0 / Gram 1 Gram 1000 Metric Ton/Day WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
2-(4-bromo-2-methylphenyl)benzonitrile
Cas No: 114772-54-2
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
Bulk 4-Bromomethyl-2-cyanobiphenyl
Cas No: 114772-54-2
USD $ 1.0-1.0 / Kilogram 1 Kilogram 10 Kilogram/Month Shaanxi Greenyo Biotech Co., Ltd. Contact Supplier

114772-54-2 Usage

Chemical Properties

Cream powder

Uses

Halogenated benzonitrile used in protein-binding studies of quinoxaline angiotensin II receptor antagonists.

114772-54-2 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Aldrich (535494)  4′-Bromomethyl-2-biphenylcarbonitrile  97% 114772-54-2 535494-25G 2,923.83CNY Detail
Aldrich (535494)  4′-Bromomethyl-2-biphenylcarbonitrile  97% 114772-54-2 535494-5G 895.05CNY Detail
Alfa Aesar (H55394)  4'-(Bromomethyl)biphenyl-2-carbonitrile, 98%    114772-54-2 25g 1820.0CNY Detail
Alfa Aesar (H55394)  4'-(Bromomethyl)biphenyl-2-carbonitrile, 98%    114772-54-2 5g 364.0CNY Detail
Alfa Aesar (H55394)  4'-(Bromomethyl)biphenyl-2-carbonitrile, 98%    114772-54-2 1g 102.0CNY Detail

114772-54-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Bromomethyl-2-cyanobiphenyl

1.2 Other means of identification

Product number -
Other names 4`-Bromomethyl-2-cyanobiphenyl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:114772-54-2 SDS

114772-54-2Synthetic route

2-Cyano-4'-methylbiphenyl
114772-53-1

2-Cyano-4'-methylbiphenyl

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions
ConditionsYield
With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane96%
With bromine In water; 1,2-dichloro-ethane at 84℃; for 0.25h; Temperature; Solvent; Irradiation; Flow reactor;96.3%
With bromine In 1,2-dichloro-ethane at 70℃; for 0.5h; Reagent/catalyst; Temperature; Time; Irradiation;94%
2-cyano-4-methylbiphenyl
64113-85-5

2-cyano-4-methylbiphenyl

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions
ConditionsYield
With 5,5-dibromohydantoin In dichloromethane at 50℃; for 0.5h; Temperature; Reagent/catalyst; Irradiation;94%
With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane at 100℃; for 2h;
2-Cyano-4'-methylbiphenyl
114772-53-1

2-Cyano-4'-methylbiphenyl

1,2-dichloro-ethane
107-06-2

1,2-dichloro-ethane

2,2'-azobis-(4-methoxy-2,4-dimethylvaleronitrile)

2,2'-azobis-(4-methoxy-2,4-dimethylvaleronitrile)

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions
ConditionsYield
With bromine In water89.4%
With N-Bromosuccinimide In water79.6%
2-Cyano-4'-methylbiphenyl
114772-53-1

2-Cyano-4'-methylbiphenyl

A

2-(4,4-dibromomethylphenyl)benzonitrile
209911-63-7

2-(4,4-dibromomethylphenyl)benzonitrile

B

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions
ConditionsYield
With N-Bromosuccinimide; Azo-bis(2,4-dimethyl-valeronitril) In dichloromethane at 45 - 50℃; for 2 - 5h; Industry scale;A n/a
B 82%
With sodium bromate; hydrogen bromide In dichloromethane; water at 0 - 20℃; UV-irradiation;A 10%
B 80%
With sodium bromate; azobis(2-cyanobutane); bromine In water; chlorobenzene at 70 - 80℃; for 6h;A n/a
B 69%
2-Cyano-4'-methylbiphenyl
114772-53-1

2-Cyano-4'-methylbiphenyl

2,2'-azobis (2,4-dimethyl valeronitrile)
4419-11-8, 108346-39-0, 108346-40-3

2,2'-azobis (2,4-dimethyl valeronitrile)

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions
ConditionsYield
With N-Bromosuccinimide In dichloromethane; water80.5%
2,2'-azobis(2-methylbutyronitrile)

2,2'-azobis(2-methylbutyronitrile)

2-Cyano-4'-methylbiphenyl
114772-53-1

2-Cyano-4'-methylbiphenyl

chlorobenzene
108-90-7

chlorobenzene

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions
ConditionsYield
With bromine75%
2-cyanobenzoic acid
3839-22-3

2-cyanobenzoic acid

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 71 percent / copper(II) oxide; potassium carbonate; potassium fluoride / palladium(II) bromide; 1,10-phenanthroline / quinoline / 24 h / 170 °C
2: 45 percent / N-bromosuccinimide; azobis(isobutyronitrile) / CCl4; cyclohexane / 18 h / 75 °C
View Scheme
ammonium 2-(aminocarbonyl)benzoate
131-63-5

ammonium 2-(aminocarbonyl)benzoate

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 72 percent / acetic anhydride; pyridine
2: 71 percent / copper(II) oxide; potassium carbonate; potassium fluoride / palladium(II) bromide; 1,10-phenanthroline / quinoline / 24 h / 170 °C
3: 45 percent / N-bromosuccinimide; azobis(isobutyronitrile) / CCl4; cyclohexane / 18 h / 75 °C
View Scheme
2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline
57598-33-1

2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrahydrofuran / 2 h / 20 °C
2: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C
3: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating
View Scheme
Multi-step reaction with 4 steps
1: magnesium / tetrahydrofuran
2: hydrogenchloride
3: thionyl chloride / water; toluene
4: dibenzoyl peroxide
View Scheme
N-(2-hydroxy-1,1-dimethyl)-2-methoxybenzamide
74201-13-1

N-(2-hydroxy-1,1-dimethyl)-2-methoxybenzamide

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: thionyl chloride / 1 h / 25 °C
2: tetrahydrofuran / 2 h / 20 °C
3: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C
4: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating
View Scheme
4,4-dimethyl-2-(4'-methyl-biphenyl-2-yl)-4,5-dihydrooxazole
84392-32-5

4,4-dimethyl-2-(4'-methyl-biphenyl-2-yl)-4,5-dihydrooxazole

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C
2: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride
2: thionyl chloride / water; toluene
3: dibenzoyl peroxide
View Scheme
2-Methoxybenzoic acid
579-75-9

2-Methoxybenzoic acid

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 95 percent / thionyl chloride / 18 h / 20 °C
2: CH2Cl2 / 2 h / 20 °C
3: thionyl chloride / 1 h / 25 °C
4: tetrahydrofuran / 2 h / 20 °C
5: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C
6: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating
View Scheme
2-Methoxybenzoyl chloride
21615-34-9

2-Methoxybenzoyl chloride

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: CH2Cl2 / 2 h / 20 °C
2: thionyl chloride / 1 h / 25 °C
3: tetrahydrofuran / 2 h / 20 °C
4: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C
5: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating
View Scheme
chlorobenzene
108-90-7

chlorobenzene

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions
ConditionsYield
In water
sodium bromate

sodium bromate

2,2'-azobis(2-methylbutyronitrile)

2,2'-azobis(2-methylbutyronitrile)

2-Cyano-4'-methylbiphenyl
114772-53-1

2-Cyano-4'-methylbiphenyl

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions
ConditionsYield
In water; chlorobenzene
In water; chlorobenzene
2,2'-azobis(2,4-dimethylvaleronitrile)

2,2'-azobis(2,4-dimethylvaleronitrile)

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

tetrachloromethane
56-23-5

tetrachloromethane

2-Cyano-4'-methylbiphenyl
114772-53-1

2-Cyano-4'-methylbiphenyl

dibenzoyl peroxide
94-36-0

dibenzoyl peroxide

A

4'-bromornethyl-2-cyanobiphenyl

4'-bromornethyl-2-cyanobiphenyl

B

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

azobisisobutyronitrile
34241-39-9

azobisisobutyronitrile

2-Cyano-4'-methylbiphenyl
114772-53-1

2-Cyano-4'-methylbiphenyl

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions
ConditionsYield
With N-Bromosuccinimide In water; chlorobenzene
With N-Bromosuccinimide In water; chlorobenzene
With N-Bromosuccinimide In tetrachloromethane
With N-Bromosuccinimide In tetrachloromethane
With N-Bromosuccinimide In tetrachloromethane
2-Cyano-4'-methylbiphenyl
114772-53-1

2-Cyano-4'-methylbiphenyl

dibenzoyl peroxide
94-36-0

dibenzoyl peroxide

A

Losartan ›DUP[753]

Losartan ›DUP[753]

B

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions
ConditionsYield
With N-Bromosuccinimide In tetrachloromethane
2-Cyano-4'-methylbiphenyl
114772-53-1

2-Cyano-4'-methylbiphenyl

dibenzoyl peroxide
94-36-0

dibenzoyl peroxide

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions
ConditionsYield
With N-Bromosuccinimide In tetrachloromethane
With N-Bromosuccinimide In tetrachloromethane
o-cyanobromobenzene
2042-37-7

o-cyanobromobenzene

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / ethanol; water; toluene / 80 °C / Inert atmosphere
2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 40 h / 80 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / N,N-dimethyl-formamide / Inert atmosphere
2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane
View Scheme
Multi-step reaction with 2 steps
1.1: palladium dichloride / methanol; toluene / 0.17 h / 20 °C / Inert atmosphere
1.2: 12 h / 110 °C / Inert atmosphere
2.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chlorobenzene / 6 h / 70 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / toluene / 6 h / 110 °C / Inert atmosphere
2: sodium bromate; sodium metabisulfite / ethyl acetate; water / 5 h / 0 - 25 °C
View Scheme
4-methylphenylboronic acid
5720-05-8

4-methylphenylboronic acid

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / ethanol; water; toluene / 80 °C / Inert atmosphere
2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 40 h / 80 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: palladium dichloride / methanol; toluene / 0.17 h / 20 °C / Inert atmosphere
1.2: 12 h / 110 °C / Inert atmosphere
2.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chlorobenzene / 6 h / 70 °C / Inert atmosphere
View Scheme
benzaldehyde N,N-dimethylhydrazone
1075-70-3

benzaldehyde N,N-dimethylhydrazone

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 4-(dimethylamino)picolinaldehyde N,N-dibenzylhydrazone; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tetrahydrofuran / 24 h / 80 °C / Inert atmosphere
2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium phosphate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
3: magnesium bis(monoperoxyphthalate)hexahydrate / methanol / 0 h / 20 °C
4: sodium metabisulfite; sodium bromate / water; ethyl acetate / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: 4-(dimethylamino)picolinaldehyde N,N-dibenzylhydrazone; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tetrahydrofuran / 24 h / 80 °C / Inert atmosphere
2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium phosphate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
3: magnesium bis(monoperoxyphthalate)hexahydrate / methanol / 0 h / 20 °C
4: sodium metabisulfite; sodium bromate / water; ethyl acetate / 20 °C
View Scheme
2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde N,N-dimethylhydrazone
1360607-13-1

2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde N,N-dimethylhydrazone

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium phosphate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
2: magnesium bis(monoperoxyphthalate)hexahydrate / methanol / 0 h / 20 °C
3: sodium metabisulfite; sodium bromate / water; ethyl acetate / 20 °C
View Scheme
4′-methyl-[1,1′-biphenyl]-2-carbaldehyde N,N-dimethylhydrazone
1404116-53-5

4′-methyl-[1,1′-biphenyl]-2-carbaldehyde N,N-dimethylhydrazone

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: magnesium bis(monoperoxyphthalate)hexahydrate / methanol / 0 h / 20 °C
2: sodium metabisulfite; sodium bromate / water; ethyl acetate / 20 °C
View Scheme
tributyl(p-tolyl)stannane
31614-66-1

tributyl(p-tolyl)stannane

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / N,N-dimethyl-formamide / Inert atmosphere
2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane
View Scheme
2-Chlorobenzonitrile
873-32-5

2-Chlorobenzonitrile

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: manganese(ll) chloride; chloro-trimethyl-silane / tetrahydrofuran / -5 - 0 °C / Inert atmosphere; Green chemistry
1.2: 9 h / -5 - 25 °C / Inert atmosphere; Green chemistry
2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / 80 °C / Green chemistry
View Scheme
4-tolylmagnesium chloride
696-61-7

4-tolylmagnesium chloride

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: manganese(ll) chloride; chloro-trimethyl-silane / tetrahydrofuran / -5 - 0 °C / Inert atmosphere; Green chemistry
1.2: 9 h / -5 - 25 °C / Inert atmosphere; Green chemistry
2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / 80 °C / Green chemistry
View Scheme
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Methyl 3-nitro-4-valerylaminobenzoate
127007-35-6

Methyl 3-nitro-4-valerylaminobenzoate

4-[(2'-Cyano-biphenyl-4-ylmethyl)-pentanoyl-amino]-3-nitro-benzoic acid methyl ester
136285-45-5

4-[(2'-Cyano-biphenyl-4-ylmethyl)-pentanoyl-amino]-3-nitro-benzoic acid methyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide for 15h; Ambient temperature;100%
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

ethyl butyroyl acetate
3249-68-1

ethyl butyroyl acetate

ethyl 2-<(2'-cyanobiphenyl-4-yl)methyl>-3-oxohexanoate
137860-26-5

ethyl 2-<(2'-cyanobiphenyl-4-yl)methyl>-3-oxohexanoate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; lithium chloride In tetrahydrofuran for 15h; Heating;98%
With N-ethyl-N,N-diisopropylamine; lithium chloride In tetrahydrofuran for 15h; Heating;
With N-ethyl-N,N-diisopropylamine; lithium chloride In tetrahydrofuran for 15h; Heating; Yield given;
L-valine benzyl ester p-toluenesulfonate salt
16652-76-9

L-valine benzyl ester p-toluenesulfonate salt

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

(S)-2-[(2'-cyanobiphenyl-4-ylmethyl)amino]-3-methylbutyric acid benzyl ester hydrochloride
137864-24-5

(S)-2-[(2'-cyanobiphenyl-4-ylmethyl)amino]-3-methylbutyric acid benzyl ester hydrochloride

Conditions
ConditionsYield
Stage #1: L-valine benzyl ester p-toluenesulfonate salt With sodium hydroxide In 5,5-dimethyl-1,3-cyclohexadiene; water at 20℃; pH=< 8.5 - 9; Large scale;
Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In 5,5-dimethyl-1,3-cyclohexadiene at 60℃; for 3.41667h; Large scale;
Stage #3: With hydrogenchloride In 5,5-dimethyl-1,3-cyclohexadiene; water at 72℃; for 2h; Dean-Stark; Large scale;
98%
Stage #1: L-valine benzyl ester p-toluenesulfonate salt; 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile With tetrabutylammomium bromide; potassium carbonate; potassium iodide In water; toluene at 50 - 55℃; for 25h;
Stage #2: With hydrogenchloride In water; toluene pH=1 - 2; Product distribution / selectivity;
90%
Stage #1: L-valine benzyl ester p-toluenesulfonate salt; 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile With tetrabutylammomium bromide; potassium carbonate; potassium iodide In water; toluene
Stage #2: With hydrogenchloride In water; toluene pH=1 - 2; Product distribution / selectivity;
90%
N-phenylpentanamide
10264-18-3

N-phenylpentanamide

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

N-((2′-cyano[1,1′-biphenyl]-4-yl)methyl)-N-phenylpentanamide

N-((2′-cyano[1,1′-biphenyl]-4-yl)methyl)-N-phenylpentanamide

Conditions
ConditionsYield
Stage #1: N-phenylpentanamide With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.166667h; Inert atmosphere;
Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere;
98%
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

N-(2'-cyanobiphenyl-4-ylmethyl)-N-propyl-amine
143096-18-8

N-(2'-cyanobiphenyl-4-ylmethyl)-N-propyl-amine

Conditions
ConditionsYield
96%
methyl 4-methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylate hydrochloride
1206680-19-4

methyl 4-methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylate hydrochloride

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

2-cyano-4'-[2
1098100-86-7

2-cyano-4'-[2"-n-propyl-4"-methyl-6"-methylcarboxylate-benzimidazole-1"-ylmethyl]biphenyl

Conditions
ConditionsYield
Stage #1: methyl 4-methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylate hydrochloride With sodium carbonate; sodium iodide In acetone
Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In acetone for 15h; Product distribution / selectivity; Reflux;
95%
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

2-Mercaptobenzothiazole
149-30-4

2-Mercaptobenzothiazole

4'-(benzothiazol-2-ylsulfanylmethyl)-biphenyl-2-carbonitrile
721970-96-3

4'-(benzothiazol-2-ylsulfanylmethyl)-biphenyl-2-carbonitrile

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile at 20℃; for 1.33333h;94.7%
2-(4-fluoro-benzylsulfanyl)-3H-quinazolin-4-thione
1429045-74-8

2-(4-fluoro-benzylsulfanyl)-3H-quinazolin-4-thione

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

C29H20FN3S2
1429045-99-7

C29H20FN3S2

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 12h; Inert atmosphere;94%
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

methyl 4-hydroxylbenzoate
99-76-3

methyl 4-hydroxylbenzoate

methyl 4-[(2'-cyanobiphenyl-4-yl)methoxy]benzoate

methyl 4-[(2'-cyanobiphenyl-4-yl)methoxy]benzoate

Conditions
ConditionsYield
With potassium carbonate In butanone at 78 - 80℃; for 2h;93.5%
2-butyl-4-(4-fluorophenyl)-1H-imidazole-5-carbaldehyde
1313233-70-3

2-butyl-4-(4-fluorophenyl)-1H-imidazole-5-carbaldehyde

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

4'-[{2-butyl-4-(4-fluorophenyl)-5-formyl-1H-imidazol-1-yl}methyl]biphenyl-2-carbonitrile
1313233-71-4

4'-[{2-butyl-4-(4-fluorophenyl)-5-formyl-1H-imidazol-1-yl}methyl]biphenyl-2-carbonitrile

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 4h;93.2%
Ethyl 3-oxoheptanoate
7737-62-4

Ethyl 3-oxoheptanoate

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

2-(2'-Cyano-biphenyl-4-ylmethyl)-3-oxo-heptanoic acid ethyl ester
137860-02-7

2-(2'-Cyano-biphenyl-4-ylmethyl)-3-oxo-heptanoic acid ethyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; lithium chloride In tetrahydrofuran for 15h; Heating;93%
With N-ethyl-N,N-diisopropylamine; lithium chloride In tetrahydrofuran for 15h; Heating;
With N-ethyl-N,N-diisopropylamine; lithium chloride In tetrahydrofuran for 15h; Heating; Yield given;
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

(6-Butyl-2-oxo-1,2-dihydro-pyridin-3-ylmethyl)-carbamic acid tert-butyl ester
147876-57-1

(6-Butyl-2-oxo-1,2-dihydro-pyridin-3-ylmethyl)-carbamic acid tert-butyl ester

6-butyl-1-(2'-cyanobiphenyl-4-ylmethyl)-1,2-dihydro-2-oxo-3-tert-butoxycarbonylaminomethyl pyridine
147876-52-6

6-butyl-1-(2'-cyanobiphenyl-4-ylmethyl)-1,2-dihydro-2-oxo-3-tert-butoxycarbonylaminomethyl pyridine

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane for 72h; Heating;92%
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

dimethyl amine
124-40-3

dimethyl amine

4'-((dimethylamino)methyl)-[1,1'-biphenyl]-2-carbonitrile
1000930-96-0

4'-((dimethylamino)methyl)-[1,1'-biphenyl]-2-carbonitrile

Conditions
ConditionsYield
In diethyl ether; water at 20℃;92%
8-bromo-7-(but-2-yn-1-yl)-3-methyl-2,,6-dihydro-1H-purine-2,6-dione
666816-98-4

8-bromo-7-(but-2-yn-1-yl)-3-methyl-2,,6-dihydro-1H-purine-2,6-dione

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

4'-((8-bromo-7-(but-2-ynyl)-3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)methyl)biphenyl-2-carbonitrile

4'-((8-bromo-7-(but-2-ynyl)-3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)methyl)biphenyl-2-carbonitrile

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 55℃; for 6h;92%
benzoimidazole
51-17-2

benzoimidazole

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

4′-((1H-benzo[d]imidazol-1-yl)methyl)-[1,1′-biphenyl]-2-carbonitrile
136285-25-1

4′-((1H-benzo[d]imidazol-1-yl)methyl)-[1,1′-biphenyl]-2-carbonitrile

Conditions
ConditionsYield
Stage #1: benzoimidazole With potassium hydroxide In dimethyl sulfoxide at 100℃; for 2h;
Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In dimethyl sulfoxide for 12h;
92%
5-methyl-3-oxo-hexanoic acid ethyl ester
34036-16-3

5-methyl-3-oxo-hexanoic acid ethyl ester

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

2-(2'-Cyano-biphenyl-4-ylmethyl)-5-methyl-3-oxo-hexanoic acid ethyl ester
137860-48-1

2-(2'-Cyano-biphenyl-4-ylmethyl)-5-methyl-3-oxo-hexanoic acid ethyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; lithium chloride In tetrahydrofuran for 15h; Heating;91%
2-propyl-1H-benzimidazole
5465-29-2

2-propyl-1H-benzimidazole

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

4’-((2-propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile
136285-23-9

4’-((2-propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile

Conditions
ConditionsYield
Stage #1: 2-propyl-1H-benzimidazole With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In N,N-dimethyl-formamide at 0 - 20℃;
91%
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 3h; Cooling with ice;70%
Stage #1: 2-propyl-1H-benzimidazole With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h; Inert atmosphere;
Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In N,N-dimethyl-formamide at 20℃; Inert atmosphere;
quinazoline-4(3H)-thione
3337-86-8

quinazoline-4(3H)-thione

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

C22H15N3S
1429045-94-2

C22H15N3S

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 12h; Inert atmosphere;91%
1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazole

1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazole

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

hydrobromide 4'-(3,4-dihydropyrimido[1,2-a]benzimidazole-10(2H)-ylmethyl) biphenyl-2-carbonitrile

hydrobromide 4'-(3,4-dihydropyrimido[1,2-a]benzimidazole-10(2H)-ylmethyl) biphenyl-2-carbonitrile

Conditions
ConditionsYield
In nitromethane for 7.5h; Heating;91%
7-amino-4-(azidomethyl)-2H-chromen-2-one
1186293-68-4

7-amino-4-(azidomethyl)-2H-chromen-2-one

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

C24H17N5O2

C24H17N5O2

Conditions
ConditionsYield
With sodium carbonate In acetone for 6h; Reflux;90.5%
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride

2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride

4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile
138401-24-8

4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 0.0208333h; microwave irradiation;90%
Stage #1: 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride With potassium carbonate; tetrabutylammomium bromide In water at 25 - 30℃; for 2h; Inert atmosphere;
Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In water at 55 - 60℃; Product distribution / selectivity;
84.2%
With tetrabutylammomium bromide; sodium hydroxide In Isopropyl acetate at 0 - 30℃; for 12h; Solvent;39%
4-amino-phenol
123-30-8

4-amino-phenol

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

4'-((4-hydroxyphenylamino)methyl)biphenyl-2-carbonitrile

4'-((4-hydroxyphenylamino)methyl)biphenyl-2-carbonitrile

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide Reflux;90%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

4'-((4-(trifluoromethyl)phenylamino)methyl)biphenyl-2-carbonitrile

4'-((4-(trifluoromethyl)phenylamino)methyl)biphenyl-2-carbonitrile

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide Reflux;90%
5-chloro-1,7’-dimethyl-2’-propyl-1H,3’H-2,5’-bibenzo[d]imidazole

5-chloro-1,7’-dimethyl-2’-propyl-1H,3’H-2,5’-bibenzo[d]imidazole

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

C33H28ClN5

C33H28ClN5

Conditions
ConditionsYield
Stage #1: 5-chloro-1,7’-dimethyl-2’-propyl-1H,3’H-2,5’-bibenzo[d]imidazole With sodium hydroxide In water; acetone for 0.5h;
Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In water; acetone at 25℃;
90%
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

(Z)-4'-(bromomethyl)-N'-hydroxy-[1,1'-biphenyl]-2-carboxamidine

(Z)-4'-(bromomethyl)-N'-hydroxy-[1,1'-biphenyl]-2-carboxamidine

Conditions
ConditionsYield
With hydroxylamine hydrochloride; sodium methylate In tetrahydrofuran; methanol at 20 - 30℃; Solvent; Reagent/catalyst; Temperature;89.9%
With hydroxylamine hydrochloride; sodium carbonate In dimethyl sulfoxide at 25 - 80℃; Reagent/catalyst; Solvent; Temperature;85.4%
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

2-nitro-aniline
88-74-4

2-nitro-aniline

4'-((2-nitrophenylamino)methyl)biphenyl-2-carbonitrile

4'-((2-nitrophenylamino)methyl)biphenyl-2-carbonitrile

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide Reflux;89%

Please post your buying leads,so that our qualified suppliers will soon contact you!

*Required Fields