1,3-Benzodioxole, 5-(bromomethyl)-6-iodo-

Base Information

• Chemical Name: 1,3-Benzodioxole, 5-(bromomethyl)-6-iodo-
• CAS No.: 153254-99-0
• Molecular Formula: C8H6BrIO2
• Molecular Weight: 340.94100
• Mol file: 153254-99-0.mol

Synonyms:3,4-methylenedioxy-2-iodobenzyl bromide;2-iodo-4,5-methylenedioxybenzyl bromide;5-(bromomethyl)-6-iodo-1,3-benzodioxole;5-Bromomethyl-6-iodo-benzo[1,3]dioxole;5-bromomethyl-6-iodobenzo[1,3]dioxole;

Chemical Property of 1,3-Benzodioxole, 5-(bromomethyl)-6-iodo-

Chemical Property:

• Melting Point: 72 - 74 °C
• PSA: 18.46000
• LogP: 2.91480

Purity/Quality:

97% ^*data from raw suppliers

5-(Bromomethyl)-6-iodobenzo[d][1,3]dioxole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-Benzodioxole, 5-(bromomethyl)-6-iodo-

There total 4 articles about 1,3-Benzodioxole, 5-(bromomethyl)-6-iodo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

6-iodo-1,3-benzodioxole-5-methanol (69048-76-6) → 5-(bromomethyl)-6-iodobenzo[d][1,3]dioxole (153254-99-0)

Guidance literature:

With phosphorus tribromide; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1016/j.tet.2004.10.105

Reference yield:

piperonol (495-76-1) → 5-(bromomethyl)-6-iodobenzo[d][1,3]dioxole (153254-99-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / I₂; silver trifluoroacetate / CHCl₃ / 0.5 h / -5 °C

2: 90 percent / conc. HBr / 2 h / 20 °C

With hydrogen bromide; iodine; silver trifluoroacetate; In chloroform;

DOI:10.1016/S0040-4020(02)00295-8

Reference yield:

piperonol (495-76-1) → 5-(bromomethyl)-6-iodobenzo[d][1,3]dioxole (153254-99-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / I₂; CF₃CO₂Ag / CHCl₃ / 0.5 h / 20 °C

2: 91 percent / PBr₃ / CH₂Cl₂ / 16 h / 20 °C

With iodine; silver trifluoroacetate; phosphorus tribromide; In dichloromethane; chloroform;

DOI:10.1016/j.tet.2004.10.105

upstream raw materials:

6-iodo-1,3-benzodioxole-5-methanol

piperonol

piperonal

Downstream raw materials:

5-(3-Benzenesulfonyl-cyclohex-2-enyloxymethyl)-6-iodo-benzo[1,3]dioxole

5-(3-Benzenesulfonyl-cyclopent-2-enyloxymethyl)-6-iodo-benzo[1,3]dioxole

5-(azidomethyl)-6-iodobenzo[d]1,3-dioxole

anhydrolycorine-7-one

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