4,6-Dichloro-5-nitronicotinic acid ethyl ester

Base Information

• Chemical Name: 4,6-Dichloro-5-nitronicotinic acid ethyl ester
• CAS No.: 154012-15-4
• Molecular Formula: C8H6Cl2N2O4
• Molecular Weight: 265.053
• Hs Code.: 2933399090
• Mol file: 154012-15-4.mol

Synonyms:ethyl 4,6-dichloro-5-nitropyridine-3-carboxylate;

Chemical Property of 4,6-Dichloro-5-nitronicotinic acid ethyl ester

Chemical Property:

• Melting Point: 36-38°
• Boiling Point: 352.9±37.0 °C(Predicted)
• PKA: -3.86±0.10(Predicted)
• PSA: 85.01000
• Density: 1.533±0.06 g/cm3(Predicted)
• LogP: 2.99650
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl4,6-Dichloro-5-nitronicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,6-Dichloro-5-nitronicotinic acid ethyl ester

There total 4 articles about 4,6-Dichloro-5-nitronicotinic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

ethyl 2,4-dihydroxy-3-nitropyridine-5-carboxylate (6317-97-1) → ethyl 2,4-dichloro-3-nitropyridine-5-carboxylate (154012-15-4)

Guidance literature:

With trichlorophosphate; at 115 ℃; for 48h;

DOI:10.1002/jhet.5570300402

Reference yield:

diethyl 1,3-acetonedicarboxylate (105-50-0) → ethyl 2,4-dichloro-3-nitropyridine-5-carboxylate (154012-15-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetic anhydride / 3 h / 130 °C

1.2: 0.5 h / 20 °C

2.1: nitric acid; sulfuric acid / 0 - 20 °C

3.1: trichlorophosphate / 24 h / 80 °C

With sulfuric acid; nitric acid; acetic anhydride; trichlorophosphate;

DOI:10.1016/j.bmc.2015.09.026

Reference yield:

4,6-dihydroxynicotinic acid ethyl ester (6975-44-6) → ethyl 2,4-dichloro-3-nitropyridine-5-carboxylate (154012-15-4)

Guidance literature:

Multi-step reaction with 2 steps

1: nitric acid; sulfuric acid / 0 - 20 °C

2: trichlorophosphate / 24 h / 80 °C

With sulfuric acid; nitric acid; trichlorophosphate;

DOI:10.1016/j.bmc.2015.09.026

upstream raw materials:

ethyl 2,4-dihydroxy-3-nitropyridine-5-carboxylate

diethyl 1,3-acetonedicarboxylate

4,6-dihydroxynicotinic acid ethyl ester

Downstream raw materials:

C₁₄H₁₀ClN₃O₃

sodium 4-[(3-bromophenyl)amino]-1-methyl-1H-imidazo[4,5-c]pyridine-7-carboxylate

4-[(2,4-dichlorophenyl)amino]-1-methyl-1H-imidazo[4,5-c]pyridine-7-carboxylic acid hydrochloride

4-[(3-chlorophenyl)oxy]-1-methyl-1H-imidazol[4,5-c]pyridine-7-carboxylic acid hydrochloride