4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester
• CAS No.: 6317-97-1
• Molecular Formula: C₈H₈N₂O₆
• Molecular Weight: 228.161
• Hs Code.: 2933399090
• Mol file: 6317-97-1.mol

Synonyms:NSC 25750

Chemical Property of 4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester

Chemical Property:

• Vapor Pressure: 3.46E-06mmHg at 25°C
• Melting Point: 243-246oC
• Boiling Point: 346.9oC at 760 mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 163.6oC
• PSA: 125.47000
• Density: 1.55g/cm3
• LogP: 1.10090
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl4,6-Dihydroxy-5-nitronicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester

There total 3 articles about 4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.6%

4,6-dihydroxynicotinic acid ethyl ester (6975-44-6) → ethyl 2,4-dihydroxy-3-nitropyridine-5-carboxylate (6317-97-1)

Guidance literature:

With sulfuric acid; nitric acid; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2015.09.026

Reference yield:

4-Hydroxy-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester (6975-44-6) → 4-hydroxy-5-nitro-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester (6317-97-1)

Guidance literature:

With sulfuric acid; nitric acid; Cooling with ice;

Reference yield:

diethyl 1,3-acetonedicarboxylate (105-50-0) → ethyl 2,4-dihydroxy-3-nitropyridine-5-carboxylate (6317-97-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic anhydride / 3 h / 130 °C

1.2: 0.5 h / 20 °C

2.1: nitric acid; sulfuric acid / 0 - 20 °C

With sulfuric acid; nitric acid; acetic anhydride;

DOI:10.1016/j.bmc.2015.09.026

upstream raw materials:

4,6-dihydroxynicotinic acid ethyl ester

diethyl 1,3-acetonedicarboxylate

4-Hydroxy-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester

Downstream raw materials:

MB₂₁₈₃₃

2,3,4-pyridinetriamine

2,4-dihydroxy-3-nitropyridine

2,4-dichloro-3-nitro-pyridine