Clofop

Base Information

• Chemical Name: Clofop
• CAS No.: 26129-32-8
• Deprecated CAS: 59621-49-7
• Molecular Formula: C15H13 Cl O4
• Molecular Weight: 292.719
• Hs Code.: 2918990090
• NSC Number: 326777
• UNII: KIH4IO8Q8Z
• DSSTox Substance ID: DTXSID90949015
• Nikkaji Number: J20.332G
• Mol file: 26129-32-8.mol

Synonyms:2-(4-(4'-chlorophenoxy)phenoxy)propionic acid;fenofibric acid;fenofibric acid potassium salt;fenofibric acid sodium salt;fenofibric acid, (R)-isomer;HCG 004

Chemical Property of Clofop

Chemical Property:

• Vapor Pressure: 3.17E-08mmHg at 25°C
• Refractive Index: 1.4429 (estimate)
• Boiling Point: 431.9 °C at 760 mmHg
• PKA: 3.22±0.10(Predicted)
• Flash Point: 215 °C
• PSA: 55.76000
• Density: 1.306 g/cm³
• LogP: 3.98420
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 292.0502366
• Heavy Atom Count: 20
• Complexity: 307

Purity/Quality:

97% ^*data from raw suppliers

2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropionic acid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(=O)O)OC1=CC=C(C=C1)OC2=CC=C(C=C2)Cl

Technology Process of Clofop

There total 8 articles about Clofop which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2N-sodium hydroxide + D-(+)-2-[4-(4-chlorophenoxy)-phenoxy]propionic acid ethyl ester (51337-67-8) → clofop (26129-32-8)

Guidance literature:

With hydrogenchloride; In methanol;

Reference yield:

D-(+)-2-[4-(4-chlorophenoxy)-phenoxy]propionic acid ethyl ester (51337-67-8) → clofop (26129-32-8)

Guidance literature:

Reference yield:

1-bromo-4-methoxy-benzene (104-92-7) → clofop (26129-32-8)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide

2: hydrogen bromide / acetic acid

3: (i) NaOEt, (ii) KOH, EtOH

With potassium hydroxide; hydrogen bromide; In acetic acid;

upstream raw materials:

4-(4-chlorophenoxy)phenol

Ethyl 2-bromopropionate

1-bromo-4-methoxy-benzene

4-(4-chlorophenoxy)anisole

Downstream raw materials:

N-Butyl-2-[4-(4-chloro-phenoxy)-phenoxy]-N-methyl-propionamide

2-[4-(4-Chloro-phenoxy)-phenoxy]-thiopropionic acid S-propyl ester

2-[4'-(4-chlorophenoxy)phenoxy]-propionic acid 4-chlorobut-1-yl ester

2-[4-(4-Chloro-phenoxy)-phenoxy]-N-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-propionamide