4-(4-Chlorophenoxy)phenol

Base Information

• Chemical Name: 4-(4-Chlorophenoxy)phenol
• CAS No.: 21567-18-0
• Molecular Formula: C12H9ClO2
• Molecular Weight: 220.655
• Hs Code.: 2909500000
• European Community (EC) Number: 627-497-2
• ChEMBL ID: CHEMBL4287279
• DSSTox Substance ID: DTXSID30492772
• Nikkaji Number: J357.647G
• Wikidata: Q72456449
• Mol file: 21567-18-0.mol

Synonyms:4-(4-chlorophenoxy)phenol;21567-18-0;4-Hydroxy-4'-chloro-diphenylether;p-(p-chlorophenoxy)phenol;4-Hydroxy-4`-chloro-diphenylether;4-(4-chloro-phenoxy)-phenol;4-Chloro-4'-hydroxydiphenyl Ether;4-(4-chlorophenoxy)-phenol;MFCD00125839;Phenol, 4-(4-chlorophenoxy)-;4(4-chlorophenoxy)-phenol;p-(p-chlorophenoxy)-phenol;4-(4'-chlorophenoxy)phenol;SCHEMBL989610;CHEMBL4287279;DTXSID30492772;XQMRZWSYBUCVAX-UHFFFAOYSA-N;4-(4-Chlorophenoxy)phenol, 97%;CS-M3652;4-Hydroxy-4'-chloro-diphenyl ether;AKOS002679464;AC-9610;GS-4317;SY030654;C2335;FT-0645194;A26495;EN300-6735793;J-014152;J-515491;4-Hydroxy-4-chloro-diphenylether;4-Chloro-4'-hydroxydiphenyl ether

Chemical Property of 4-(4-Chlorophenoxy)phenol

Chemical Property:

• Vapor Pressure: 3.43E-05mmHg at 25°C
• Melting Point: 80-85 °C
• Refractive Index: 1.615
• Boiling Point: 343.927 °C at 760 mmHg
• Flash Point: 161.801 °C
• PSA: 29.46000
• Density: 1.295 g/cm³
• LogP: 3.83790
• Storage Temp.: 2-8°C
• XLogP3: 4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 220.0291072
• Heavy Atom Count: 15
• Complexity: 182

Purity/Quality:

99% ^*data from raw suppliers

4-(4-Chlorophenoxy)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-41-43
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1O)OC2=CC=C(C=C2)Cl

Technology Process of 4-(4-Chlorophenoxy)phenol

There total 13 articles about 4-(4-Chlorophenoxy)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-Chloro-4-fluorobenzene (352-33-0) + hydroquinone (123-31-9,8027-02-9) → 4-(4-chlorophenoxy)phenol (21567-18-0)

Guidance literature:

With potassium tert-butylate; In dimethyl sulfoxide; at 170 ℃; for 24h;

DOI:10.1016/j.tetlet.2005.09.025

Reference yield: 93.3%

4-phenoxyanilin (139-59-3) → 4-(4-chlorophenoxy)phenol (21567-18-0)

Guidance literature:

Reference yield: 52.0%

4-(4-chlorophenoxy)anisole (40843-46-7) → 4-(4-chlorophenoxy)phenol (21567-18-0)

Guidance literature:

4-(4-chlorophenoxy)anisole; With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 2.08333h;

With water; In dichloromethane; at 0 ℃; Product distribution / selectivity;

upstream raw materials:

4-(4-chlorophenoxy)anisole

4-(4-chlorophenoxy)phenyl acetate

4-(4'-chlorophenoxy)benzaldehyde

1-Chloro-4-fluorobenzene

Downstream raw materials:

2-chloro-4-(4-chloro-phenoxy)-phenol

4-(4-chlorophenoxy)-phenoxy-isobutyric acid

1-[4-(4-Chloro-phenoxy)-phenoxy]-2-methyl-propan-2-ol

2-[4-(4-Chloro-phenoxy)-phenoxy]-propionic acid allyl ester