8-Phenyl-2-thiomorpholin-4-yl-chromen-4-one

Base Information

Chemical Name:8-Phenyl-2-thiomorpholin-4-yl-chromen-4-one
CAS No.:154447-37-7
Molecular Formula:C19H17NO2S
Molecular Weight:323.415
Hs Code.:
ChEMBL ID:CHEMBL175944
DSSTox Substance ID:DTXSID501216809
Mol file:154447-37-7.mol

Synonyms:CHEMBL175944;8-phenyl-2-thiomorpholin-4-yl-chromen-4-one;DTXSID501216809;BDBM50159630;154447-37-7;PD183366;8-Phenyl-2-(4-thiomorpholinyl)-4H-1-benzopyran-4-one

Suppliers and Price of 8-Phenyl-2-thiomorpholin-4-yl-chromen-4-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-Phenyl-2-thiomorpholin-4-yl-chromen-4-one

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:323.09799996
Heavy Atom Count:23
Complexity:466

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CSCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4

Technology Process of 8-Phenyl-2-thiomorpholin-4-yl-chromen-4-one

There total 3 articles about 8-Phenyl-2-thiomorpholin-4-yl-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 842122-27-4
1-(N-thiomorpholinyl)-3-(3-phenyl-2-hydroxyphenyl)propan-1,3-dione

: 154447-37-7
8-phenyl-2-thiomorpholin-4-yl-chromen-4-one

Guidance literature:: With trifluoromethylsulfonic anhydride; In dichloromethane; at 0 ℃; for 20h;
DOI:10.1021/jm049526a

Reference yield:

: 23863-19-6
N-acetylthiomorpholine

: 154447-37-7
8-phenyl-2-thiomorpholin-4-yl-chromen-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran; hexane / 1.5 h / -10 °C

1.2: 42 percent / tetrahydrofuran; hexane / 16 h / 25 °C

2.1: 44 percent / triflic anhydride / CH₂Cl₂ / 20 h / 0 °C

With trifluoromethylsulfonic anhydride; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm049526a

Reference yield:

: 4906-69-8
methyl 2-hydroxy-3-phenylbenzoate

: 154447-37-7
8-phenyl-2-thiomorpholin-4-yl-chromen-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran; hexane / 1.5 h / -10 °C

1.2: 42 percent / tetrahydrofuran; hexane / 16 h / 25 °C

2.1: 44 percent / triflic anhydride / CH₂Cl₂ / 20 h / 0 °C

With trifluoromethylsulfonic anhydride; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm049526a