4906-69-8Relevant academic research and scientific papers
Cascade dimerization of 2-styryl-1,1-cyclopropanedicarboxylate upon treatment with gallium trichloride
Novikov,Tarasova,Denisov,Korolev,Tomilov, Yu. V.
, p. 2628 - 2638 (2016)
2-Styrylcyclopropane-1,1-dicarboxylate treated with anhydrous gallium trichloride undergoes dimerization with the cyclopropane ring opening and the styryl substituent double bond involvement, leading to the formation of polysubstituted cyclic and bicyclic structures with the predominance of the former or the latter depending on the reaction conditions. Most compounds are formed with very high diastereoselectivity. Thirteen major and minor dimeric structures were isolated and reliably characterized, two of which were found to additionally include a chlorine atom. A rare for the reactions of donor-acceptor cyclopropanes example of the formation of a product with the fused cyclobutane ring was effected at–80 °C. Plausible mechanisms of observed processes were discussed.
Anticancer agent synthesis designed by artificial intelligence: Pd(OAc)2-catalyzed one-pot preparation of biphenyls and its application to a concise synthesis of various diazofluorenes
Hayashi, Natsumi,Masuko, Takashi,Okada, Syo,Takabatake, Tetsuhiko,Tomita, Hiroki,Toyota, Masahiro
supporting information, (2020/09/01)
We successfully synthesized the antitumor agent 1-methoxydiazofluorene via an artificial intelligence (AI)-proposed design. The pivotal biphenyl scaffold of 1-methoxydiazofluorene was constructed by applying Pd(OAc)2-catalyzed cycloaromatizatio
Regioselective synthesis of functionalized biaryls based on the first [3+3] cyclocondensations of 4-Aryl-1,3-bis(trimethylsilyloxy)buta-1,3-dienes
Adeel, Muhammad,Rashid, Muhammad A.,Rasool, Nasir,Ahmad, Rasheed,Villinger, Alexander,Reinke, Helmut,Fischer, Christine,Langer, Peter
experimental part, p. 243 - 250 (2009/06/27)
Sterically encumbered biaryls were regioselectively prepared by formal [3+3] cyclocondensations of novel 4-aryl-1,3- bis(trimethylsilyloxy)-1,3-dienes. Georg Thieme Verlag Stuttgart · New York.
Substitution of hydroxybiaryls via directed ortho-lithiation of N-silylated O-aryl N-isopropylcarbamates
Kauch, Matthias,Snieckus, Victor,Hoppe, Dieter
, p. 7149 - 7158 (2007/10/03)
Herein we report regioselective substitution reactions of a series of 2- and 3-hydroxybiaryls including BINOL via a new directed ortho-metalation procedure. O-Aryl N-isopropylcarbamates, conveniently prepared from phenols and isopropyl isocyanate, are tem
Synthetic studies of the phosphatidylinositol 3-kinase inhibitor LY294002 and related analogues
Abbott, Belinda,Thompson, Philip
, p. 1099 - 1106 (2007/10/03)
Synthetic methodologies have been developed for the direct and high-yielding preparation of the phosphatidyl-inositol 3-kinase inhibitor LY294002. These methods are readily amenable to the efficient generation of analogues, which will facilitate a detailed investigation of this important family of enzymes.
