Acetic acid,2-(1-methyl-4-piperidinylidene)-,methyl ester

Base Information

• Chemical Name: Acetic acid,2-(1-methyl-4-piperidinylidene)-,methyl ester
• CAS No.: 154594-25-9
• Molecular Formula: C9H15NO2
• Molecular Weight: 169.22100
• Hs Code.: 2933399990
• Mol file: 154594-25-9.mol

Synonyms:1-Methyl 1,2,3,6-Tetrahydropyridin-4-yl acetic acid methyl ester;methyl 2-(1-methylpiperidin-4-ylidene)ethanoate;

Chemical Property of Acetic acid,2-(1-methyl-4-piperidinylidene)-,methyl ester

Chemical Property:

• Vapor Pressure: 0.0349mmHg at 25°C
• Boiling Point: 241.9oC at 760 mmHg
• Flash Point: 93.7oC
• PSA: 29.54000
• Density: 1.093g/cm3
• LogP: 0.74930

Purity/Quality:

97% ^*data from raw suppliers

methyl2-(1-methylpiperidin-4-ylidene)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetic acid,2-(1-methyl-4-piperidinylidene)-,methyl ester

There total 1 articles about Acetic acid,2-(1-methyl-4-piperidinylidene)-,methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

1-Methyl-4-piperidone (1445-73-4) + Methyl diethylphosphonoacetate (1067-74-9) → (1-Methyl-piperidin-4-ylidene)-acetic acid methyl ester (154594-25-9)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 60 ℃;

DOI:10.1016/0960-894X(96)00324-1

Reference yield: 89.0%

(1-Methyl-piperidin-4-ylidene)-acetic acid methyl ester (154594-25-9) → N-Methyl-4-(carbomethoxymethylidenyl)piperidine (95533-25-8)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; water;

DOI:10.1016/0960-894X(96)00324-1

Reference yield:

(1-Methyl-piperidin-4-ylidene)-acetic acid methyl ester (154594-25-9) → 1-methyl-4 (formylmethyl)piperidine (10333-64-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / H₂, 5N HCl / Pd-C / methanol; H₂O

2: 1) DIBAL-H, 2) (COCl)2, DMSO, Et₃N / 1) toluene, -35 deg C -> 25 deg C, 2) CH₂Cl₂, -70 deg C

With hydrogenchloride; oxalyl dichloride; hydrogen; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In methanol; water;

DOI:10.1016/0960-894X(96)00324-1

upstream raw materials:

1-Methyl-4-piperidone

Methyl diethylphosphonoacetate

Downstream raw materials:

N-Methyl-4-(carbomethoxymethylidenyl)piperidine

1-methyl-4 (formylmethyl)piperidine