Technology Process of 2,4(1H,3H)-Pyrimidinedione, 5-[[3-(3-fluorophenoxy)phenyl]methyl]-
There total 6 articles about 2,4(1H,3H)-Pyrimidinedione, 5-[[3-(3-fluorophenoxy)phenyl]methyl]- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
acetic acid; chloroacetic acid;
for 6h;
Heating;
DOI:10.1021/jm960688j
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) NaOMe / 1.) MeOH, RT, 3 h, 2.) N-methyl-2-pyrrolidinone, 180 deg C, 24 h
2: 79 percent / Et3N, Pd(OAc)2, tri-o-tolylphosphine / acetonitrile / 5 h / 100 °C
3: 93 percent / H2 / PtO2 / ethanol / 6 h / 1551.4 Torr
4: 1.) potassium tert-butoxide / 1.) Et2O, THF, RT, 18 h, 2.) 2-propanol, reflux, 5 h
5: 91 percent / 20percent aq. chloroacetic acid, gl. AcOH / 6 h / Heating
With
palladium diacetate; potassium tert-butylate; hydrogen; sodium methylate; acetic acid; triethylamine; chloroacetic acid; tris-(o-tolyl)phosphine;
platinum(IV) oxide;
In
ethanol; acetonitrile;
DOI:10.1021/jm960688j
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) NaOMe / 1.) MeOH, RT, 3 h, 2.) N-methyl-2-pyrrolidinone, 180 deg C, 24 h
2: 79 percent / Et3N, Pd(OAc)2, tri-o-tolylphosphine / acetonitrile / 5 h / 100 °C
3: 93 percent / H2 / PtO2 / ethanol / 6 h / 1551.4 Torr
4: 1.) potassium tert-butoxide / 1.) Et2O, THF, RT, 18 h, 2.) 2-propanol, reflux, 5 h
5: 91 percent / 20percent aq. chloroacetic acid, gl. AcOH / 6 h / Heating
With
palladium diacetate; potassium tert-butylate; hydrogen; sodium methylate; acetic acid; triethylamine; chloroacetic acid; tris-(o-tolyl)phosphine;
platinum(IV) oxide;
In
ethanol; acetonitrile;
DOI:10.1021/jm960688j