1h-Indole-3-acetamide,1-benzoyl-5-methoxy-2-methyl-

Base Information

• Chemical Name: 1h-Indole-3-acetamide,1-benzoyl-5-methoxy-2-methyl-
• CAS No.: 1568-30-5
• Molecular Formula: C₁₉H₁₈N₂O₃
• Molecular Weight: 322.364
• DSSTox Substance ID: DTXSID60441894
• Nikkaji Number: J805.083J
• Wikidata: Q82258893
• ChEMBL ID: CHEMBL148940
• Mol file: 1568-30-5.mol

Synonyms:1568-30-5;CHEMBL148940;1h-indole-3-acetamide,1-benzoyl-5-methoxy-2-methyl-;DTXSID60441894;2-(1-BENZOYL-5-METHOXY-2-METHYLINDOL-3-YL)ACETAMIDE;BDBM50055777;2-(1-Benzoyl-2-methyl-5-methoxy-1H-indol-3-yl)acetamide;2-(1-Benzoyl-5-methoxy-2-methyl-1H-indol-3-yl)-acetamide

Chemical Property of 1h-Indole-3-acetamide,1-benzoyl-5-methoxy-2-methyl-

Chemical Property:

• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 322.13174244
• Heavy Atom Count: 24
• Complexity: 475

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C2=C(N1C(=O)C3=CC=CC=C3)C=CC(=C2)OC)CC(=O)N

Technology Process of 1h-Indole-3-acetamide,1-benzoyl-5-methoxy-2-methyl-

There total 3 articles about 1h-Indole-3-acetamide,1-benzoyl-5-methoxy-2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Methoxy-2-methylindole-3-acetic acid (2882-15-7) → 2-(1-benzoyl-5-methoxy-2-methyl-indol-3-yl)-acetamide (1568-30-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Et₃N, ethyl chloroformate, 2.) NH₃ gas / 1.) THF, 30 min, 2.) THF, 3 h

2: 1.) NaH / 1.) DMF, 1 h ,2.) DMF, 4 h

With ammonia; chloroformic acid ethyl ester; sodium hydride; triethylamine;

DOI:10.1021/jm960485v

Reference yield:

2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide (15992-10-6) + benzoyl chloride (98-88-4) → 2-(1-benzoyl-5-methoxy-2-methyl-indol-3-yl)-acetamide (1568-30-5)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 1 h ,2.) DMF, 4 h;

DOI:10.1021/jm960485v

Reference yield:

→ 2-(1-benzoyl-5-methoxy-2-methyl-indol-3-yl)-acetamide (1568-30-5)

Guidance literature:

Aus entsp. 1-H-Indol mit NaH/Benzoylchlorid;

upstream raw materials:

2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide

benzoyl chloride

5-Methoxy-2-methylindole-3-acetic acid