4-Hydroxy-2-naphthoic acid

Base Information

• Chemical Name: 4-Hydroxy-2-naphthoic acid
• CAS No.: 1573-91-7
• Molecular Formula: C11H8O3
• Molecular Weight: 188.17900
• Hs Code.: 2918199890
• European Community (EC) Number: 886-652-4
• Nikkaji Number: J167.278I
• Mol file: 1573-91-7.mol

Synonyms:4-hydroxy-2-naphthoic acid;1573-91-7;4-hydroxynaphthalene-2-carboxylic acid;2-Naphthalenecarboxylic acid, 4-hydroxy-;MFCD12405016;4-Hydroxy-2-naphthalenecarboxylic acid;1-Hydroxy-3-naphthoic acid;4-Hydroxy-2-naphthoic acid;2-Naphthalenecarboxylic acid,4-hydroxy-;4-hydroxy-2-naphthoicacid;1-hydroxy-3-naphthoic acid;SCHEMBL163553;NIOAVQYSSKOCQP-UHFFFAOYSA-N;BAA57391;CS-B0399;AKOS022505551;4-Hydroxy-naphthalene-2-carboxylic acid;CS-13416;SY029163;EN300-116154;F51110;Z1255420559

Chemical Property of 4-Hydroxy-2-naphthoic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 182-183 °C
• Boiling Point: 411.632oC at 760 mmHg
• PKA: 4.08±0.30(Predicted)
• Flash Point: 216.901oC
• PSA: 57.53000
• Density: 1.399g/cm3
• LogP: 2.24360
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 188.047344113
• Heavy Atom Count: 14
• Complexity: 227

Purity/Quality:

97% ^*data from raw suppliers

4-Hydroxy-2-naphthalenecarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=C(C=C2O)C(=O)O

Technology Process of 4-Hydroxy-2-naphthoic acid

There total 12 articles about 4-Hydroxy-2-naphthoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

trans-phenylitaconic acid (5653-88-3,65756-81-2,46427-07-0) → 3-hydroxynaphthoic acid (1573-91-7)

Guidance literature:

With sulfuric acid; at 20 ℃; for 8h;

DOI:10.1007/s12272-013-0240-1

Reference yield: 65.0%

2-benzylidenesuccinic acid (5653-88-3) → 3-hydroxynaphthoic acid (1573-91-7)

Guidance literature:

With sulfuric acid; at 20 ℃; for 48h; Inert atmosphere;

Reference yield: 6.3%

naphthalene-2-carboxylate (93-09-4) → 3-hydroxynaphthoic acid (1573-91-7)

Guidance literature:

With tetrakis(pentafluorophenyl)porphyrin manganese(III) chloride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetonitrile; at 27 ℃; for 1h; regioselective reaction; Inert atmosphere;

DOI:10.1002/poc.3012

upstream raw materials:

4-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

4-amino-[2]naphthonitrile

4-Amino-[2]naphthoesaeure

N,N-diethylaniline

Downstream raw materials:

4-methoxynaphthalene-2-carbaldehyde

methyl 4-methoxynaphthalene-2-carboxylate

methyl 4-hydroxy-2-naphthalenecarboxylate

4-methoxy-2-naphthoic acid