2-Naphthalenecarboxylic acid, 4-methoxy-, methyl ester

Base Information

• Chemical Name: 2-Naphthalenecarboxylic acid, 4-methoxy-, methyl ester
• CAS No.: 33295-47-5
• Molecular Formula: C13H12O3
• Molecular Weight: 216.23
• Hs Code.: 2916399090
• Mol file: 33295-47-5.mol

Synonyms:methyl 4-methoxy-2-naphthoate; Methyl-4-methoxy-2-naphthoat

Chemical Property of 2-Naphthalenecarboxylic acid, 4-methoxy-, methyl ester

Chemical Property:

• Vapor Pressure: 4.69E-05mmHg at 25°C
• Melting Point: 202.0-202.5 °C
• Boiling Point: 349.5°C at 760 mmHg
• Flash Point: 145.3°C
• PSA: 35.53000
• Density: 1.166g/cm³
• LogP: 2.63500

Purity/Quality:

≥95% ^*data from raw suppliers

4-Methoxy-2-naphthalenecarboxylicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Naphthalenecarboxylic acid, 4-methoxy-, methyl ester

There total 6 articles about 2-Naphthalenecarboxylic acid, 4-methoxy-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-hydroxynaphthoic acid (1573-91-7) + methyl iodide (74-88-4) → methyl 4-methoxynaphthalene-2-carboxylate (33295-47-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 18 - 25 ℃; for 12h;

Reference yield:

methyl 4-hydroxy-2-naphthalenecarboxylate (34205-71-5) + methyl iodide (74-88-4) → methyl 4-methoxynaphthalene-2-carboxylate (33295-47-5)

Guidance literature:

With potassium carbonate;

Reference yield:

1,3-Dihydro-1,1-dimethoxyisobenzofuran (59567-96-3) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 4-methoxynaphthalene-2-carboxylate (33295-47-5) + methyl 1-methoxy-2-naphthoate (6039-59-4) + 4-Hydroxy-1-methoxy-3,4-dihydro-naphthalene-2-carboxylic acid methyl ester (77341-83-4) + (1S,8R,9S)-8-Methoxy-11-oxa-tricyclo[6.2.1.02,7]undeca-2(7),3,5-triene-9-carboxylic acid methyl ester (77341-82-3)

Guidance literature:

acetic acid; In toluene; for 120h; Title compound not separated from byproducts; Heating;

DOI:10.1021/jo00326a027

upstream raw materials:

1,3-Dihydro-1,1-dimethoxyisobenzofuran

acrylic acid methyl ester

3-hydroxynaphthoic acid

dimethyl sulfate

Downstream raw materials:

4-methoxynaphthalene-2-carbaldehyde