Tert-butyl 4-formyl-4-phenylpiperidine-1-carboxylate

Base Information

Chemical Name:Tert-butyl 4-formyl-4-phenylpiperidine-1-carboxylate
CAS No.:158144-80-0
Molecular Formula:C17H23NO3
Molecular Weight:289.375
Hs Code.:
DSSTox Substance ID:DTXSID501187979
Mol file:158144-80-0.mol

Synonyms:tert-butyl 4-formyl-4-phenylpiperidine-1-carboxylate;158144-80-0;SCHEMBL442118;DTXSID501187979;FT-0743084;EN300-4353959;Z1505717103;1,1-Dimethylethyl 4-formyl-4-phenyl-1-piperidinecarboxylate

Suppliers and Price of Tert-butyl 4-formyl-4-phenylpiperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Tert-butyl 4-formyl-4-phenylpiperidine-1-carboxylate

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:289.16779360
Heavy Atom Count:21
Complexity:372

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(CC1)(C=O)C2=CC=CC=C2

Technology Process of Tert-butyl 4-formyl-4-phenylpiperidine-1-carboxylate

There total 4 articles about Tert-butyl 4-formyl-4-phenylpiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 158144-79-7
tert-butyl 4-cyano-4-phenylpiperidine-1-carboxylate

: 158144-80-0
1-Boc-4-phenyl-4-piperidinecarbaldehyde

Guidance literature:: tert-butyl 4-cyano-4-phenylpiperidine-1-carboxylate; With diisobutylaluminium hydride; In toluene; at -78 - -35 ℃; Inert atmosphere;

With methanol; In toluene; Inert atmosphere;
DOI:10.1021/jm800598a

Reference yield:

: 51304-58-6
4-cyano-4-phenylpiperidine hydrochloride

: 158144-80-0
1-Boc-4-phenyl-4-piperidinecarbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / Et₃N / CH₂Cl₂ / 20 °C

2: 53 percent / diisobutylaluminum hydrire (DIBAL-H) / toluene / 4 h / -78 °C

With diisobutylaluminium hydride; triethylamine; In dichloromethane; toluene;
DOI:10.1002/ejoc.200400698

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 158144-80-0
1-Boc-4-phenyl-4-piperidinecarbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / Et₃N / CH₂Cl₂ / 20 °C

2: 53 percent / diisobutylaluminum hydrire (DIBAL-H) / toluene / 4 h / -78 °C

With diisobutylaluminium hydride; triethylamine; In dichloromethane; toluene;
DOI:10.1002/ejoc.200400698