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51304-58-6 Usage


4-CYANO-4-PHENYLPIPERIDINE HYDROCHLORIDE is a white to off-white crystalline powder that serves as a versatile intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its unique chemical structure, which includes a cyano group and a phenyl ring attached to a piperidine core.


Used in Pharmaceutical Industry:
4-CYANO-4-PHENYLPIPERIDINE HYDROCHLORIDE is used as a reactant for the synthesis of various pharmaceutical compounds, including:
1. CCR5 antagonists derived at the N-terminal of the piperidine ring: These compounds are designed to inhibit the chemokine receptor 5, which plays a role in HIV-1 infection and certain inflammatory diseases.
2. Substituted piperidines as ligands of chemokine receptor 5 and inhibitors of HIV-1: These ligands can potentially block the entry of HIV-1 into host cells, providing a therapeutic approach to combat the virus.
3. Functionalized nitrogen heterocycles by radical decarboxylation of βand γ-amino acids: This application involves the synthesis of nitrogen-containing heterocycles, which are important building blocks for various biologically active compounds.
4. Benzovesamicol analogs as potential imaging probes for vesicular acetylcholine transporters: These analogs can be used to study the function and regulation of vesicular acetylcholine transporters, which are involved in the release of acetylcholine in the nervous system.
5. Neurotransmitter transporter inhibitors with activity at dopamine receptor sites: These inhibitors can modulate the activity of dopamine transporters, which are important targets for the treatment of neurological and psychiatric disorders.
6. α1a Adrenoceptor-selective antagonists: These antagonists can selectively block the α1a adrenoceptor, which is involved in various physiological processes, including blood pressure regulation and prostate function.

Check Digit Verification of cas no

The CAS Registry Mumber 51304-58-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,3,0 and 4 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 51304-58:
86 % 10 = 6
So 51304-58-6 is a valid CAS Registry Number.

51304-58-6 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
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  • Price
  • Detail
  • Alfa Aesar

  • (H28414)  4-Cyano-4-phenylpiperidine hydrochloride, 97%   

  • 51304-58-6

  • 1g

  • 256.0CNY

  • Detail
  • Alfa Aesar

  • (H28414)  4-Cyano-4-phenylpiperidine hydrochloride, 97%   

  • 51304-58-6

  • 10g

  • 1118.0CNY

  • Detail
  • Aldrich

  • (C94408)  4-Cyano-4-phenylpiperidinehydrochloride  97%

  • 51304-58-6

  • C94408-10G

  • 1,466.01CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017


1.1 GHS Product identifier


1.2 Other means of identification

Product number -
Other names 4-phenylpiperidine-4-carbonitrile,hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:51304-58-6 SDS

51304-58-6Relevant articles and documents



Paragraph 0475-0476, (2020/12/11)

Described herein are compounds that act as CYP46A1 inhibitors, compositions comprising these compounds, and methods of their use into treating neurodegenerative diseases and the like, or a pharmaceutically active salt thereof. The present invention relates to compounds represented by the formula wherein each symbol is as defined in the specification, or a pharmaceutically active salt thereof.

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