2H-Benz[e]isoindole-1-carboxylic acid, 3-[[5-formyl-3-(3-methoxy-3-oxopropyl)-4-methyl-1H-pyrrol-2-yl]methyl]-4 ,5-dihydro-, phenylmethyl ester

Base Information

• Chemical Name: 2H-Benz[e]isoindole-1-carboxylic acid, 3-[[5-formyl-3-(3-methoxy-3-oxopropyl)-4-methyl-1H-pyrrol-2-yl]methyl]-4 ,5-dihydro-, phenylmethyl ester
• CAS No.: 159469-73-5
• Molecular Formula: C₃₁H₃₀N₂O₅
• Molecular Weight: 510.59
• Mol file: 159469-73-5.mol

Synonyms:

Chemical Property of 2H-Benz[e]isoindole-1-carboxylic acid, 3-[[5-formyl-3-(3-methoxy-3-oxopropyl)-4-methyl-1H-pyrrol-2-yl]methyl]-4 ,5-dihydro-, phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2H-Benz[e]isoindole-1-carboxylic acid, 3-[[5-formyl-3-(3-methoxy-3-oxopropyl)-4-methyl-1H-pyrrol-2-yl]methyl]-4 ,5-dihydro-, phenylmethyl ester

There total 6 articles about 2H-Benz[e]isoindole-1-carboxylic acid, 3-[[5-formyl-3-(3-methoxy-3-oxopropyl)-4-methyl-1H-pyrrol-2-yl]methyl]-4 ,5-dihydro-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-acetyl-1-tetralone (17216-08-9) → benzyl 3-(5-formyl-3-(2-(methoxycarbonyl)ethyl)-4-methylpyrrol-2-ylmethyl)-4,5-dihydronaphtho[1,2-c]pyrrole-1-carboxylate (159469-73-5)

Guidance literature:

Multi-step reaction with 6 steps

1: 78 percent / acetic acid / Heating

2: NaOCH₂Ph

3: acetic acid

4: Montmorillonite Clay

5: TFA

With montmorillonite clay; trifluoroacetic acid; sodium phenyl-methanolate; In acetic acid;

DOI:10.1016/0040-4039(94)80100-2

Reference yield:

Ethyl 3-methyl-4,5-dihydro-2H-benzoisoindole-1-carboxylate (81979-59-1) → benzyl 3-(5-formyl-3-(2-(methoxycarbonyl)ethyl)-4-methylpyrrol-2-ylmethyl)-4,5-dihydronaphtho[1,2-c]pyrrole-1-carboxylate (159469-73-5)

Guidance literature:

Multi-step reaction with 5 steps

1: NaOCH₂Ph

2: acetic acid

3: Montmorillonite Clay

4: TFA

With montmorillonite clay; trifluoroacetic acid; sodium phenyl-methanolate; In acetic acid;

DOI:10.1016/0040-4039(94)80100-2

Reference yield:

benzyl 3-acetoxymethyl-4,5-dihydronaphtho<1,2-c>pyrrole-1-carboxylate (159469-62-2) → benzyl 3-(5-formyl-3-(2-(methoxycarbonyl)ethyl)-4-methylpyrrol-2-ylmethyl)-4,5-dihydronaphtho[1,2-c]pyrrole-1-carboxylate (159469-73-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / montmorillonite clay K₁₀ / CH₂Cl₂

2: trifluoroacetic acid / 0 - 20 °C

With Montmorillonite clay K₁₀; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jo040269r

upstream raw materials:

trimethyl orthoformate

benzyl 3-(5-tert-butyloxycarbonyl-3-(2-(methoxycarbonyl)ethyl)-4-methylpyrrol-2-ylmethyl)-4,5-dihydronaphtho[1,2-c]pyrrole-1-carboxylate

benzyl 3-acetoxymethyl-4,5-dihydronaphtho<1,2-c>pyrrole-1-carboxylate

2-acetyl-1-tetralone