Propanal, 2-[(phenylmethoxy)methoxy]-, (2R)-

Base Information

• Chemical Name: Propanal, 2-[(phenylmethoxy)methoxy]-, (2R)-
• CAS No.: 159572-27-7
• Molecular Formula: C11H14O3
• Molecular Weight: 194.23
• DSSTox Substance ID: DTXSID50447643
• Nikkaji Number: J271.140K
• Wikidata: Q82266517
• Mol file: 159572-27-7.mol

Synonyms:159572-27-7;Propanal, 2-[(phenylmethoxy)methoxy]-, (2R)-;SCHEMBL17502411;DTXSID50447643;(R)-2-(Benzyloxymethoxy)propanal

Chemical Property of Propanal, 2-[(phenylmethoxy)methoxy]-, (2R)-

Chemical Property:

• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 194.094294304
• Heavy Atom Count: 14
• Complexity: 153

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C=O)OCOCC1=CC=CC=C1
• Isomeric SMILES: C[C@H](C=O)OCOCC1=CC=CC=C1

Technology Process of Propanal, 2-[(phenylmethoxy)methoxy]-, (2R)-

There total 5 articles about Propanal, 2-[(phenylmethoxy)methoxy]-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

Methyl (R)-2-benzyloxymethoxypropanoate (260978-31-2) → (R)-2-((benzyloxy)methoxy)propanal (159572-27-7)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -78 ℃; for 2h;

Reference yield: 75.0%

2-Methylpropyl (R)-2-(benzyloxymethoxy)propanoate (154674-77-8) → (R)-2-((benzyloxy)methoxy)propanal (159572-27-7)

Guidance literature:

With diisobutylaluminium hydride; In hexane; at -78 ℃; for 1.5h;

DOI:10.1039/a805856c

Reference yield:

Benzyloxymethyl chloride (3587-60-8) + Isobutyl (R)-lactate (61597-96-4,73523-02-1) → (R)-2-((benzyloxy)methoxy)propanal (159572-27-7)

Guidance literature:

Benzyloxymethyl chloride; Isobutyl (R)-lactate; With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane;

With lithium aluminium tetrahydride; In diethyl ether;

upstream raw materials:

2-Methylpropyl (R)-2-(benzyloxymethoxy)propanoate

Methyl (R)-2-benzyloxymethoxypropanoate

Benzyloxymethyl chloride

(R)-2-(benzyloxymethoxy)propan-1-ol

Downstream raw materials:

(2R,3R,4S)-2-(benzyloxymethoxy)-4-methylhex-5-en-3-ol

(2R,3R)-2-Benzyloxymethoxy-pentan-3-ol

(2R,3R)-5-(chloromethyl)-2-[(phenylmethoxy)methoxy]hex-5-en-3-ol

(S)-2-[(2R,3R)-3-Benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-6-(1,1-dimethyl-allyl)-3,4-dihydro-2H-pyran