4-(3,4-dihydro-2(1H)-isoquinolinyl)-1-(4-fluorophenyl)-1-butanone

Base Information

• Chemical Name: 4-(3,4-dihydro-2(1H)-isoquinolinyl)-1-(4-fluorophenyl)-1-butanone
• CAS No.: 15997-82-7
• Molecular Formula: C19H20FNO
• Molecular Weight: 297.372
• Mol file: 15997-82-7.mol

Synonyms:4-(3,4-Dihydro-1H-isoquinolin-2-yl)-1-(4-fluoro-phenyl)-butan-1-one;2-((4-(4-Fluorophenyl)-4-oxobutyl))-1,2,3,4-tetrahydroisoquinoline;2-<γ-(4-Fluorbenzoyl)-propyl)>-1,2,3,4-tetrahydro-isochinolin;

Chemical Property of 4-(3,4-dihydro-2(1H)-isoquinolinyl)-1-(4-fluorophenyl)-1-butanone

Chemical Property:

• Melting Point: 104 - 105 °C
• PSA: 20.31000
• LogP: 3.78480

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3,4-dihydro-2(1H)-isoquinolinyl)-1-(4-fluorophenyl)-1-butanone

There total 3 articles about 4-(3,4-dihydro-2(1H)-isoquinolinyl)-1-(4-fluorophenyl)-1-butanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

1,2,3,4-tetrahydroisoquinoline (91-21-4) + 4-(4-fluorophenyl)-4-oxo-n-butyl chloride (3874-54-2,41167-07-1) → 4-(3,4-dihydroisoquinolin-2(1H)-yl)-1-(4-fluorophenyl)butan-1-one (15997-82-7)

Guidance literature:

With potassium carbonate; potassium iodide; In 1,2-dimethoxyethane; at 120 ℃; for 1h; Microwave irradiation; Sealed tube;

DOI:10.1016/j.bmc.2016.05.053

Reference yield:

2-[3-((2-(4-Fluorophenyl)-1,3-dioxolan-2-yl))propyl]-1,2,3,4-tetrahydroisoquinoline → 4-(3,4-dihydroisoquinolin-2(1H)-yl)-1-(4-fluorophenyl)butan-1-one (15997-82-7)

Guidance literature:

With hydrogenchloride; In methanol;

Reference yield:

→ 4-(3,4-dihydroisoquinolin-2(1H)-yl)-1-(4-fluorophenyl)butan-1-one (15997-82-7)

Guidance literature:

Tetrahydroisochinolin 1B, Oxidation mit MnO2;

upstream raw materials:

1,2,3,4-tetrahydroisoquinoline

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

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