4-(3,4,5-Trifluorophenyl)cyclohexane-1-carbaldehyde

Base Information

Chemical Name:4-(3,4,5-Trifluorophenyl)cyclohexane-1-carbaldehyde
CAS No.:160148-06-1
Molecular Formula:C13H13F3O
Molecular Weight:242.241
Hs Code.:
DSSTox Substance ID:DTXSID90597631
Nikkaji Number:J2.716.426I

Synonyms:4-(3,4,5-trifluorophenyl)cyclohexane-1-carbaldehyde;160148-06-1;SCHEMBL7859003;SCHEMBL8736458;AMY8874;DTXSID90597631;NFHOVIGMSHFLFI-KYZUINATSA-N;NFHOVIGMSHFLFI-UHFFFAOYSA-N;4(3,4,5-trifluoro phenyl) cyclohexanecarboaldehyde;4-(3,4,5-trifluorophenyl) cyclohexanecarboaldehyde;4-(3,4,5-trifluorophenyl)cyclohexane carboaldehyde;Trans-4-(3,4,5-trifluorophenyl) cyclohexanecarbaldehyde

Suppliers and Price of 4-(3,4,5-Trifluorophenyl)cyclohexane-1-carbaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 4-(3,4,5-Trifluorophenyl)cyclohexane-1-carbaldehyde

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:242.09184952
Heavy Atom Count:17
Complexity:251

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(CCC1C=O)C2=CC(=C(C(=C2)F)F)F

Technology Process of 4-(3,4,5-Trifluorophenyl)cyclohexane-1-carbaldehyde

There total 2 articles about 4-(3,4,5-Trifluorophenyl)cyclohexane-1-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 160910-31-6
4-(3',4',5'-trifluorophenyl)methoxymethylenecyclohexane

: 160148-06-1
trans-4-(3,4,5-trifluorophenyl)cyclohexanecarbaldehyde

Guidance literature:: 4-(3',4',5'-trifluorophenyl)methoxymethylenecyclohexane; With formic acid; In toluene; at 20 ℃; for 18h;

With sodium hydroxide; In methanol; at 20 ℃; for 1h; Further stages.;
DOI:10.1021/ja010024l

Reference yield:

: 160148-05-0
4-(3',4',5'-trifluorophenyl)cyclohexanone

: 160148-06-1
trans-4-(3,4,5-trifluorophenyl)cyclohexanecarbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: t-BuOK / tetrahydrofuran / -10 - 20 °C

2.1: HCO₂H / toluene / 18 h / 20 °C

2.2: NaOH / methanol / 1 h / 20 °C

With formic acid; potassium tert-butylate; In tetrahydrofuran; toluene;
DOI:10.1021/ja010024l

Reference yield: 95.0%

: 2612-28-4
2-propyl-propane-1,3-diol

: 160148-06-1
trans-4-(3,4,5-trifluorophenyl)cyclohexanecarbaldehyde

: trans-5-propyl-2-(trans-4-(3,4,5-trifluorophenyl)cyclohexyl)-1,3-dioxane

Guidance literature:: With hydrogenchloride; calcium chloride; In water; at 50 ℃; for 18h; Reagent/catalyst; Temperature; Time; stereoselective reaction; Inert atmosphere; Large scale;
DOI:10.1021/acs.oprd.8b00408