4-(3',4',5'-trifluorophenyl)methoxymethylenecyclohexane

Base Information

• Chemical Name: 4-(3',4',5'-trifluorophenyl)methoxymethylenecyclohexane
• CAS No.: 160910-31-6
• Molecular Formula: C₁₄H₁₅F₃O
• Molecular Weight: 256.268
• Mol file: 160910-31-6.mol

Synonyms:4-(3',4',5'-trifluorophenyl)methoxymethylenecyclohexane

Chemical Property of 4-(3',4',5'-trifluorophenyl)methoxymethylenecyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-(3',4',5'-trifluorophenyl)methoxymethylenecyclohexane

There total 2 articles about 4-(3',4',5'-trifluorophenyl)methoxymethylenecyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(methoxymethyl)triphenylphosphonium chloride (4009-98-7) + 4-(3',4',5'-trifluorophenyl)cyclohexanone (160148-05-0) → 4-(3',4',5'-trifluorophenyl)methoxymethylenecyclohexane (160910-31-6)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at -10 - 20 ℃;

DOI:10.1021/ja010024l

Reference yield:

→ 4-(3',4',5'-trifluorophenyl)methoxymethylenecyclohexane (160910-31-6)

Guidance literature:

Reference yield: 90.0%

2-propyl-propane-1,3-diol (2612-28-4) + 4-(3',4',5'-trifluorophenyl)methoxymethylenecyclohexane (160910-31-6) → 5-propyl-2-(trans-4-(3,4,5-trifluorophenyl)cyclohexyl)-1,3-dioxane

Guidance literature:

With p-toluenesulfonic acid monohydrate; 1-butyl-2,3-methylimidazolium tetrafluoroborate; at 30 - 80 ℃; for 26h; Inert atmosphere;

upstream raw materials:

(methoxymethyl)triphenylphosphonium chloride

4-(3',4',5'-trifluorophenyl)cyclohexanone

Downstream raw materials:

trans-4-(3,4,5-trifluorophenyl)cyclohexanecarbaldehyde

1,2,3-Trifluoro-5-{4-[(E)-2-(4-propyl-cyclohexyl)-vinyl]-cyclohexyl}-benzene

4-(3,4,5-trifluorophenyl)cyclohexanecarbaldehyde