L-Phenylalanine, 4-[(diethoxyphosphinyl)difluoromethyl]-

Base Information

Chemical Name:L-Phenylalanine, 4-[(diethoxyphosphinyl)difluoromethyl]-
CAS No.:160751-42-8
Molecular Formula:C14H20F2NO5P
Molecular Weight:351.287
Hs Code.:
DSSTox Substance ID:DTXSID10471207
Nikkaji Number:J1.946.504G
Wikidata:Q82299660

Synonyms:L-Phenylalanine, 4-[(diethoxyphosphinyl)difluoromethyl]-;160751-42-8;SCHEMBL2423462;DTXSID10471207;SNSFIWGJZZYFDH-LBPRGKRZSA-N;(S)-2-Amino-3-(4-((diethoxyphosphoryl)difluoromethyl)phenyl)propanoic acid

Suppliers and Price of L-Phenylalanine, 4-[(diethoxyphosphinyl)difluoromethyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of L-Phenylalanine, 4-[(diethoxyphosphinyl)difluoromethyl]-

Chemical Property:

XLogP3:-0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:9
Exact Mass:351.10471606
Heavy Atom Count:23
Complexity:431

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOP(=O)(C(C1=CC=C(C=C1)CC(C(=O)O)N)(F)F)OCC
Isomeric SMILES:CCOP(=O)(C(C1=CC=C(C=C1)C[C@@H](C(=O)O)N)(F)F)OCC

Technology Process of L-Phenylalanine, 4-[(diethoxyphosphinyl)difluoromethyl]-

There total 5 articles about L-Phenylalanine, 4-[(diethoxyphosphinyl)difluoromethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 174678-81-0
(3S,5S,6R)-3-{4-[(Diethoxy-phosphoryl)-difluoro-methyl]-benzyl}-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester

: 160751-42-8
4-<(diethylphosphono)difluoromethyl>-L-phenylalanine

Guidance literature:: With hydrogen; palladium dichloride; In tetrahydrofuran; methanol; ethanol; for 20h; under 2585.7 Torr;
DOI:10.1021/jo9517508

Reference yield:

: 6232-88-8
4-bromomethylbenzoic Acid

: 160751-42-8
4-<(diethylphosphono)difluoromethyl>-L-phenylalanine

Guidance literature:: Multi-step reaction with 5 steps

1: phosphorus tribromide / 3 h / Heating

2: 1.9 g / toluene / 0.67 h / 0 °C

3: 52 percent / (diethylamido)sulfur trifluoride / Ambient temperature

4: 78 percent / hexamethylphosphoramide, LiN(TMS)2 / tetrahydrofuran / 0.75 h / -78 °C

5: 100 percent / H₂ / PdCl₂ / ethanol; tetrahydrofuran; methanol / 20 h / 2585.7 Torr

With N,N,N,N,N,N-hexamethylphosphoric triamide; (diethylamido)sulfur trifluoride; hydrogen; phosphorus tribromide; lithium hexamethyldisilazane; palladium dichloride; In tetrahydrofuran; methanol; ethanol; toluene;
DOI:10.1021/jo9517508

Reference yield:

: 876-07-3
4-(bromomethyl)benzoyl bromide

: 160751-42-8
4-<(diethylphosphono)difluoromethyl>-L-phenylalanine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.9 g / toluene / 0.67 h / 0 °C

2: 52 percent / (diethylamido)sulfur trifluoride / Ambient temperature

3: 78 percent / hexamethylphosphoramide, LiN(TMS)2 / tetrahydrofuran / 0.75 h / -78 °C

4: 100 percent / H₂ / PdCl₂ / ethanol; tetrahydrofuran; methanol / 20 h / 2585.7 Torr

With N,N,N,N,N,N-hexamethylphosphoric triamide; (diethylamido)sulfur trifluoride; hydrogen; lithium hexamethyldisilazane; palladium dichloride; In tetrahydrofuran; methanol; ethanol; toluene;
DOI:10.1021/jo9517508